Abstract： Objective： To observe the clinical effect of Jianpi Yishen Xiezhuo Decoction on early type 2 diabetic kidney disease (T2DKD) and its effect on the immunologic function of patients. Methods ： A total of 120 patients with early T2DKD were selected and divided into the control group and the Jianpi group according to the random number table method，with 60 cases in each group. The control group was given the routine treatment， including blood glucose and blood pressure control and administration of western medicine， and the Jianpi group was additionally treated with Jianpi Yishen Xiezhuo Decoction based on the treatment of the control group. Both groups were treated for 60 days. The clinical effects，and the levels of kidney function indexes， including cystatin C (Cys- C)， C- reactive protein (CRP)， urinary albumin excretion rate (UAER) and creatinine clearance rate (CCr)， serum immunologic function indexes， including CD4 + and CD8 + ， serum inflammatory factors， including tumor necrosis factor- α (TNF- α) and interleukin- 6 (IL- 6) and vascular endothelial growth factor (VEGF) were compared before and after treatment between the two groups. Results：After treatment，the total effective rate was 88.33% in the Jianpi group，higher than that of 71.67% in the control group (P＜0.05). After treatment，the levels of Cys- C， CRP and UAER in both groups were decreased (P＜0.05)， and the CCr levels were increased (P＜ 0.05)；the levels of Cys- C and UAER in the Jianpi group were lower than those in the control group (P＜ 0.05)，and the CCr level was higher than that in the control group (P＜0.05). After treatment，the levels of CD4+ and CD4+/CD8+ in both groups were decreased (P＜0.05)，and the CD8+ levels were increased (P＜ 0.05)；the levels of CD4+ and CD4+/CD8+ in the Jianpi group were lower than those in the control group (P＜ 0.05). After treatment， the levels of VEGF， TNF- α and IL- 6 in both groups were decreased (P＜0.05)， and the levels of VEGF and TNF-α in the Jianpi group were lower than those in the control group (P＜0.05). Conclusion： Jianpi Yishen Xiezhuo Decoction has a significant curative effect on early T2DKD disease， which can effectively improve the kidney function indexes and immunologic function of patients，inhibit the inflammatory responses of the body and delay the further progress of renal damage.