目的：观察补阴益肾方联合芬吗通治疗卵巢功能早衰的疗效。方法：选取168 例卵巢功能早衰患 者，按随机数字表法分为研究组与对照组各84 例。对照组给予芬吗通治疗，研究组给予补阴益阴方联合芬吗 通治疗，3 个疗程结束后评估2 组临床疗效。比较2 组治疗前后中医证候积分、性激素指标[血清卵泡刺激 素（FSH）、黄体生成素（LH）、雌二醇（E2） ]、卵巢储备功能[抑制素B（INHB）、抗缪勒管激素（AMH） ]及 子宫内膜厚度的变化。结果：观察组临床疗效总有效率为90.48%，对照组为79.76%，2 组比较，差异有统计 学意义（P＜0.05）。治疗后，2 组中医证候主症、次症及总积分均较治疗前下降（P＜0.05），研究组上述3 项 指标值均低于对照组（P＜0.05）。治疗后，2 组FSH、LH 水平均较治疗前下降（P＜0.05），E2 水平均较治疗前 上升（P＜0.05）；研究组FSH、LH 水平均低于对照组（P＜0.05），E2 水平高于对照组（P＜0.05）。治疗后， 2 组INHB、AMH 水平、子宫内膜厚度均较治疗前升高（P＜0.05），研究组上述3 项指标值均高于对照 组（P＜0.05）。结论：补阴益肾方联合芬吗通治疗卵巢功能早衰疗效确切，可有效缓解患者症状，改善性激素 水平及卵巢储备功能，增加子宫内膜厚度。
Abstract： Objective： To observe the clinical effect of Buyin Yishen Prescription combined with Femoston for premature ovarian failure. Methods：A total of 168 cases of patients with premature ovarian failure were selected and divided into the study group and the control group according to the random number table method，with 84 cases in each group. The control group was treated with Femoston，and the study group was treated with Buyin Yishen Prescription combined with Femoston. After three courses of treatment， the clinical effects in the two groups was evaluated. The changes of traditional Chinese medicine (TCM) syndrome scores， sex hormone indexes， ovarian reserve function and endometrial thickness were compared before and after treatment between the two groups. Results：The total effective rate of clinical effect was 90.48% in the observation group and 79.76% in the control group，the difference being significant (P＜0.05). After treatment， the main symptoms and secondary symptoms of TCM syndromes and the total scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three indexes in the study group were lower than those in the control group (P＜0.05). After treatment， the levels of FSH and LH in the two groups were decreased when compared with those before treatment (P＜0.05)，and E2 levels were increased when compared with those before treatment (P＜0.05)； the levels of FSH and LH in the study group were lower than those in the control group (P＜0.05)， and the level of E2 was higher than that in the control group (P＜0.05). After treatment，the levels of INHB and AMH and the endometrial thickness in the two groups were increased when compared with those before treatment (P＜0.05)， and the above levels in the study group were higher than those in the control group (P＜0.05). Conclusion： Buyin Yishen Prescription combined with Femoston has a definite curative effect on regulating premature ovarian failure， which can effectively relieve symptoms，improve sex hormones and ovarian reserve function，increase endometrial thickness.