目的：观察吴茱萸贴敷涌泉穴联合有氧运动治疗老年慢性失眠的疗效。方法：选取86 例老年慢性 失眠患者，按随机数字表法分为对照组及观察组各43 例。对照组予以有氧运动治疗，观察组予以吴茱萸贴敷 涌泉穴联合有氧运动治疗。观察2 组临床疗效，比较2 组治疗前后匹兹堡睡眠质量指数量表（PSQI） 评分、 阿森斯失眠量表（AIS） 评分、脑内γ-氨基丁酸（GABA）、乙酰胆碱（ACH）、5-羟色胺（5-HT） 水平及艾司 唑仑用量的变化。结果：观察组临床疗效总有效率为90.70%，对照组为72.09%，2 组比较，差异有统计学意 义（P＜0.05）。治疗后，2 组PSQI、AIS 评分均较治疗前下降（P＜0.05），观察组PSQI、AIS 评分均低于对照 组（P＜0.05）。治疗后，2 组脑GABA、ACH、5-HT 相对功率均较治疗前上升（P＜0.05），观察组上述3 项指 标值均高于对照组（P＜0.05）。治疗后，2 组艾司唑仑用量均较治疗前减少（P＜0.05），观察组用量少于对照 组（P＜0.05）。结论：吴茱萸贴敷涌泉穴联合有氧运动治疗老年慢性失眠疗效确切，可促进患者睡眠质量改 善，有效调节神经递质水平，减少失眠药物使用量。
Abstract：Objective：To observe the clinical effect of the therapy of application with Fructus Evodiae at Yongquan Point (KI 1) combined with aerobic exercise on senile chronic insomnia. Methods： A total of 86 patients with senile chronic insomnia were selected and divided into the control group and the observation group according to random number table method， with 43 cases in each group. The control group was treated with aerobic exercise， and the observation group was given application with Fructus Evodiae at Yongquan Point combined with aerobic exercise. The clinical effects in the two groups were observed， and the changes in the scores of Pittsburgh Sleep Quality Index (PSQI) and Assens Insomnia Scale (AIS)，the levels of brain γ-aminobutyric acid (GABA)，acetylcholine (ACH) and 5-hydroxytryptamine (5-HT)，and the dosage of esazolam before and after treatment were compared between the two groups. Results： The total clinical effective rate was 90.70% in the observation group and 72.09% in the control group， the difference being significant (P＜0.05). After treatment， PSQI and AIS scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the PSQI and AIS scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of GABA， ACH and 5- HT of brain in the two groups were increased when compared with those before treatment (P＜0.05)， and the above three levels in the observation group were higher than those in the control group (P＜0.05). After treatment， the dosage of esazolam in the two groups was respectively decreased when compared with that before treatment (P＜0.05)，and the dosage in the observation group was lower than that in the control group (P＜0.05). Conclusion： The therapy of application with Fructus Evodiae at Yongquan Point combined with aerobic exercise has a definite therapeutic effect on senile chronic insomnia，which can promote the improvement of sleep quality，effectively regulate the levels of neurotransmitter and reduce the use of medicine for insomnia.