Abstract：Objective：To observe the clinical effect of modified Chaihu Shugan San Decoction combined with routine therapy for senile patients with schizophrenia complicated with insomnia. Methods：A total of 96 cases of patients with schizophrenia complicated with insomnia of liver qi stagnation type were included and divided into two groups according to the random number table method，with 48 cases in each group. Both groups were given symptomatic supportive treatment and the oral administration of Estazolam Tablets and Amisulpride Tablets， and the trial group was additionally treated with modified Chaihu Shugan San Decoction. Both groups were treated for 8 weeks. Before and after treatment，the scores of Positive and Negative Syndrome Scale (PANSS) and Pittsburgh Sleep Quality Index (PSQI) were evaluated；the levels of interleukin- 6 (IL- 6) and tumor necrosis factor- α (TNF- α) in serum and γ- aminobutyric acid (GABA) and glutamic acid (Glu) in plasma were measured. The clinical effects were compared between the two groups. The occurrence of adverse reactions was observed. Results：After 8 weeks of treatment，the total curative effective rates of schizophrenia and insomnia in the trial group were higher than those in the control group (P＜0.05). The scores of negative symptoms， positive symptoms， psychopathological symptoms and other symptoms in PANSS in the two groups were lower than those before treatment (P＜0.05)，and the above four scores in the trial group were lower than those in the control group (P＜0.05). The PSQI scores of subjective sleep quality，daytime function，sleep latency，use of sleep medication，sleep disturbances， sleep duration，and habitual sleep efficiency as well as the total scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the trial group were lower than those in the control group (P＜0.05). The levels of IL-6 and TNF-α in serum and GABA in plasma in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of Glu in plasma were increased when compared with those before treatment (P＜0.05). The levels of IL- 6 and TNF- α in serum and GABA in plasma in the trial group were lower than those in the control group (P＜ 0.05)， and the level of Glu in plasma was higher than that in the control group (P＜0.05). There was no significant difference being found in the comparison of the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion：Modified Chaihu Shugan San Decoction combined with routine therapy has a significant curative effect in treating senile patients with schizophrenia complicated with insomnia of liver qi stagnation type，which can reduce the symptoms of schizophrenia and improve the sleep quality.