Abstract： Objective： To observe the clinical effect of the therapy of Shenfu Injection combined with early continuous blood purification on septic shock and its effect on aerobic metabolism and microcirculation. Methods：A total of 100 patients with septic shock were selected as the study objects and randomly divided into the control group and the treatment group，with 50 cases in each group. The control group was given early continuous blood purification for treatment，and the treatment group was additionally treated with Shenfu Injection based on the treatment of the control group. Before and after treatment，the scores of Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation Scoring System (APACHE Ⅱ)， and the levels of blood gas indexes， including oxygen delivery (DO2)， oxygen consumption (VO2) and oxygen extraction ratio (O2ER) and sublingual microcirculation indexes， including total vessel density (TVD)，proportion of perfused vessels (PPV)，perfused vessel density (PVD) and microvascular flow density (MFI) were compared between the two groups. Results：The total effective rate was 90.00% in the treatment group and 74.00% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of scores of SOFA and APACHE Ⅱ between the two groups (P＞0.05). After treatment， the scores of SOFA and APACHEⅡ in both groups were decreased when compared with those before treatment (P＜0.05)，and the above two scores in the treatment group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of DO2，VO2 and O2ER between the two groups (P＞0.05). After treatment，the levels of DO2 and VO2 in both groups were increased when compared with those before treatment (P＜0.05)， and the O2ER levels were decreased when compared with those before treatment (P＜0.05)； the levels of DO2 and VO2 in the treatment group were higher than those in the control group (P＜0.05)，and the O2ER level was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of TVD，PVD，PPV and MFI between the two groups (P＞0.05). After treatment，the levels of above four sublingual microcirculation indexes in both groups were increased when compared with those before treatment (P＜0.05)，and the above four levels in the treatment group were higher than those in the control group (P＜0.05). Conclusion： The therapy of Shenfu Injection combined with early continuous blood purification has a good curative effect on patients with septic shock， which can significantly improve the aerobic metabolism and microcirculation of the body and thus effectively mitigate the state of disease.