Abstract： Objective： To observe the clinical effect of Bushen Xiezhuo Prescription combined with conventional therapy on diabetic kidney disease. Methods：A total of 96 diabetic kidney disease patients of kidney deficiency and turbidity accumulation type were divided into the observation group and the control group according to random number table method， with 48 cases in each group. The two groups were treated with the same conventional symptomatic treatment plans of modern medicine，and the observation group was additionally treated with Bushen Xiezhuo Prescription. Both groups were treated for 8 weeks. The traditional Chinese medicine syndrome scores and the levels of blood glucose indexes， including fasting blood glucose， 2- hour postprandial blood glucose (P2hBG) and glycated hemoglobin， blood lipid indexes，including triglycerides (TG)，low density lipoprotein cholesterol (LDL-C)，high density lipoprotein cholesterol (HDL- C) and total cholesterol (TC)， kidney function indexes， including urea nitrogen， blood creatinine，urinary albumin excretion rate and 24-hour urinary protein quantity，were evaluated before and after treatment. The clinical effects and adverse reactions in the two groups were analyzed. Results：After treatment，the total effective rate in the observation group was higher than that in the control group，the difference being significant (P＜0.05). The scores of clear and long- time urination or urination frequency， turbid urine，fatigue，waist and knee soreness and weakness，pale complexion，and limb edema in the two groups were all decreased when compared with those before treatment (P＜0.05)，and the above six scores in the observation group were lower than those in the control group (P＜0.05). The fasting blood glucose，P2hBG and glycated hemoglobin in the two groups were all decreased when compared with those before treatment (P＜0.05)，and the three indexes in the observation group were lower than those in the control group (P＜0.05). The levels of TG ， LDL- C and TC in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of the above three indexes in the observation group were lower than those in the control group (P＜0.05). The HDL-C levels in both groups were increased when compared with those before treatment (P ＜ 0.05) ， and the HDL-C level in the observation group was higher than that in the control group (P＜0.05). The levels of urea nitrogen，serum creatinine，urinary albumin excretion rate and 24- hour urinary protein quantity in the two groups were all decreased when compared with those before treatment (P＜0.05)， and the above four indexes in the observation group were lower than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The application of Bushen Xiezhuo Prescription combined with conventional therapy for diabetic kidney disease patients of kidney deficiency and turbidity accumulation type can effectively control blood glucose levels， regulate abnormal blood lipid， improve the kidney function， and help delay disease progression without serious adverse reactions.