Abstract： Objective： To observe the effect of periodic therapy of cultivating the vital essence and resolving stasis on ovarian function and recurrence rates of patients with metrorrhagia and metrostaxis in perimenopausal period. Methods： A total of 80 cases of patients with metrorrhagia and metrostaxis who met the inclusion criteria were randomly divided into the treatment group and the control group ， with 40 cases in each group. The control group was treated with Dydrogesterone Tablets， and the treatment group was additionally treated with periodic therapy of cultivating the vital essence and resolving stasis based on the treatment plan of the control group. Vaginal bleeding， changes in ovarian function， and recurrence rates in the two groups were observed before and after treatment. Results：The total effective rate of hemostasis was 92.5% in the treatment group and 87.5% in the control group， there being no significant difference (P＞0.05). The total hemostatic effects in the two groups were compared by Mann- Whitney test，the difference being significant (P＜0.05)，and the curative effect in the treatment group was better than that in the control group. After treatment，the levels of basal follicle-stimulating hormone (FSH) and FSH/ luteinizing hormone (LH) in the treatment group were lower than those in the control group， estradiol (E2) and anti- mullerian hormone (AMH) were higher than those in the control group，differences being significant (P＜0.05). Conclusion：In the treatment of patients with metrorrhagia and metrostaxis in perimenopausal period，the periodic therapy of cultivating the vital essence and resolving stasis combined with Dydrogesterone Tablets is superior to simple treatment with Dydrogesterone Tablets in hemostasis， improving ovarian function.