Abstract：Objective：To observe the clinical effect of Tongnao Huoluo Acupuncture Method combined with Huayu Tongmai Xiaobi Decoction for cerebral infarction in acute stage with wind- phlegm stasis syndrome. Methods： A total of 62 cases of patients with cerebral infarction in acute stage with windphlegm stasis syndrome were selected and divided into the observation group and the control group according to the random number table method， with 31 cases in each group. Both groups were treated with routine western medicine； the control group was additionally treated with Huayu Tongmai Xiaobi Decoction，and the observation group was additionally treated with Tongnao Huoluo Acupuncture Method combined with Huayu Tongmai Xiaobi Decoction. Both groups were treated for 3 weeks. The clinical effects， hemorheology indexes， blood lipid indexes， cerebrovascular reserve function， blood flow velocity of middle cerebral artery， and levels of brain- derived neurotrophic factor (BDNF)， intercellular adhesion molecule- 1 (ICAM- 1)， insulin- like growth factor- 1 (IGF- 1) and vascular endothelial growth factor (VEGF) in serum were compared between the two groups. Results： After treatment， the total effective rate was 96.77% in the observation group，higher than that of 80.65% in the control group (P＜ 0.05). Hematocrit (HCT)，platelet adhesion rate (PAR)，and fibrinogen (FIB) levels in the two groups were decreased when compared with those before treatment (P＜0.05)，and HCT，PAR，and FIB levels in the observation group were lower than those in the control group (P＜0.05). The levels of triglyceride (TG)，total cholesterol (TC)， and low- density lipoprotein cholesterol (LDL- C) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of TG，TC，and LDL-C in serum in the observation group were lower than those in the control group (P＜0.05). The levels of highdensity lipoprotein cholesterol (HDL- C) in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the level of HDL- C in serum in the observation group was higher than that in the control group (P＜0.05). The cerebrovascular reserve function and peak systolic blood flow velocity (Vs)，end- diastolic blood flow velocity (Vd) and mean blood flow velocity (Vm) of middle cerebral artery in the two groups were increased when compared with those before treatment (P＜0.05)，and the cerebrovascular reserve function and Vs， Vd and Vm of middle cerebral artery in the observation group were higher than those in the control group (P＜0.05). The levels of BDNF，IGF-1，and VEGF in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of BDNF，IGF- 1，and VEGF in serum in the observation group were higher than those in the control group (P＜0.05). The levels of ICAM- 1 in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and level of ICAM-1 in serum in the observation group was lower than that in the control group (P＜0.05). Conclusion： Tongnao Huoluo Acupuncture Method combined with Huayu Tongmai Xiaobi Decoction for cerebral infarction in acute stage with wind- phlegm stasis syndrome can improve hemorheology，regulate blood lipids，enhance cerebrovascular reserve function，and promote the recovery of neurological function.