Abstract： Objective： To observe the effectiveness and safety of umbilical moxibustion with bamboo salt combined with health guidance for fatigue in sub- health state. Methods：A total of 134 patients with fatigue in sub-health state were included and randomly divided into the control group and the intervention group. Both groups received health guidance intervention， and the intervention group received umbilical moxibustion with bamboo salt. The intervention time was 4 weeks in the two groups. Before and after intervention，the trunk fatigue scores，mental fatigue scores，and total scores of Fatigue Scale-14 (FS-14)， and subjective fatigue degree in Visual Analogue Scale (VAS) were evaluated. The acceptance of umbilical moxibustion with bamboo salt among patients in the intervention group was evaluated，and the incidence of discomfort symptoms or adverse reactions was observed during the process of umbilical moxibustion with bamboo salt. Results： After intervention， the trunk fatigue score and mental fatigue score in the intervention group were decreased when compared with those before treatment (P＜0.05)；there was no significant difference being found in the comparison of trunk fatigue score and mental fatigue score before and after intervention in the control group (P＞0.05)；the trunk fatigue score and mental fatigue score in the intervention group were lower than those in the control group (P＜0.05). The total score of FS- 14 in the intervention group was decreased when compared with that before treatment (P＜0.05)； there was no significant difference being found in the comparison of the total score of FS-14 in control group before and after intervention (P＞0.05)；the total score of FS- 14 in the intervention group was lower than that in the control group (P＜0.05). The VAS scores of subjective fatigue degree in the two groups were decreased when compared with those before treatment (P＜0.05)， and the VAS score of subjective fatigue in the intervention group was lower than that in the control group (P＜0.05). After 5 times of interventions，the scores of fear of cold， low back pain， sleep disorders， menstrual irregularities， abdominal distension， poor appetite， cold diarrhea， emotional anxiety， and fecal obstruction in the intervention group were decreased when compared with those before treatment，differences being significant (P＜0.05). No patient reported any discomfort or adverse reactions during the process of umbilical moxibustion with bamboo salt. Conclusion： On the basis of health guidance， the additional application of umbilical moxibustion with bamboo salt can effectively improve the fatigue status and related clinical symptoms of people with fatigue in sub- health state，the umbilical moxibustion with bamboo salt has the advantages of simple operation， safety and effectiveness，and easy acceptance by patients.