Abstract： Objective： To observe the clinical effect of the therapy of Buyang Huoxue Prescription combined with Sacubitril Valsartan Sodium Tablets on patients with acute exacerbation of chronic heart failure of yang qi depletion and blood stasis type. Methods：Using retrospective analysis，the clinical data of 84 patients with acute exacerbation of chronic heart failure of yang qi depletion and blood stasis type were analyzed，and the 84 patients were divided into the control group and the observation group according to different treatment methods， with 42 cases in each group. Both groups were treated with western medicine such as Sacubitril Valsartan Sodium Tablets，and the observation group was additionally treated with Buyang Huoxue Prescription. The traditional Chinese medicine(TCM) syndrome scores，the 6-minute walk distance， heart function indexes， including left ventricular ejection fraction， left ventricular endsystolic diameter (LVESD) and left ventricular end- diastolic diameter (LVESD)， the myocardial enzyme， including N-terminal pro-brain natriuretic peptide (NT-proBNP)，and the indexes of inflammatory factors， including interleukin- 6 (IL- 6) and hypersensitive C- reactive protein (hs- CRP) were compared before and after treatment between the two groups ； the clinical effects and incidence of adverse reactions were compared between the two groups. Results：After 3 months of treatment，the total effective rate in the observation group was higher than that in the control group (P＜0.05). The TCM syndrome scores in the two groups were decreased when compared with those before treatment，and the 6-minute walk distance in the two groups were increased when compared with those before treatment，differences being significant (P＜0.05). The TCM syndrome score in the observation group was lower than that in the control group，and the 6- minute walk distance was longer than that in the control group， differences being significant (P＜ 0.05). The LVEF values in both groups were increased when compared with those before treatment，and the values of LVESD and LVEDD in both groups were decreased when compared with those before treatment，differences being significant (P＜0.05). The LVEF value in the observation group was higher than that in the control group，and the values of LVESD and LVEDD were lower than those in the control group， differences being significant (P＜0.05). The levels of NT- proBNP，IL- 6 and hs- CRP in both groups were decreased when compared with those before treatment (P＜0.05)，and the above levels in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05). Conclusion：The therapy of Buyang Huoxue Prescription combined with Sacubitril Valsartan Sodium Tablets has a significant curative effect on patients with acute exacerbation of chronic heart failure of yang qi depletion and blood stasis syndrome type，which can not only mitigate the symptoms earlier，but also improve the heart function，and reduce myocardial injuries with good safety.