Abstract： Objective： To observe the clinical effect of Feilike Mixtures combined with western medicine on elderly patients with cough variant asthma (CVA). Methods：A total of 98 cases of CVA patients were divided into the control group and the observation group according to the random number table method，with 49 cases in each group. The control group was treated with conventional western medicine， and the observation group was additionally treated with the oral administration of Feilike Mixtures based on the treatment of the control group. Both groups were continuously treated for half a month. Clinical effects were evaluated in the two groups. Traditional Chinese medicine (TCM) syndrome scores， the lung function，and the levels of inflammatory factors in serum were compared between the two groups before and after treatment. The incidence of adverse reactions was observed. Results：The total effective rate was 95.92% in the observation group， higher than that of 81.63% in the control group (P＜0.05). After treatment， TCM scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and each TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). After treatment，peak expiratory flow (PEF)，the forced expiratory volume in one second (FEV1)，and the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) in the two groups were increased when compared with those before treatment (P＜0.05)，and the above three levels in the observation group were higher than those in the control group (P ＜ 0.05). After treatment ， the levels of tumor necrosis factor- α (TNF- α) ， interleukin- 6 (IL-6)，and interleukin- 8 (IL-8) in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of TNF-α，IL-6，and IL-8 in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group， the difference being significant (χ 2=4.009， P=0.045). Conclusion： Feilike Mixtures combined with western medicine has good clinical effects on elderly CVA patients，which can improve clinical symptoms and the lung function and reduce inflammatory factors levels and adverse reactions.