Abstract：Objective：To observe the clinical effect of Jingangteng Capsules combined with Cefoxitin Sodium Injection in the treatment of pelvic inflammatory disease and its effect on the levels of microRNA- 34 (miR- 34) and silent information regulator 1 (SIRT1) in serum. Methods：A total of 94 cases of patients with pelvic inflammatory disease were divided into the control group and the observation group according to the random number table method， with 47 cases in each group. The control group was treated with Cefoxitin Sodium Injection， and the observation group was treated with Jingangteng Capsules combined with Cefoxitin Sodium Injection. Both groups were treated for 2 weeks. Traditional Chinese medicine (TCM) syndrome scores and the levels of miR-34a and SIRT1 in serum were compared before and after treatment between the two groups. The pelvic fluid volume， C- reactive protein (CRP)， white blood cell count (WBC)，and neutrophil count (NEUT) were compared before and after treatment between the two groups； the disappearance time of symptoms (lower abdominal pain， excessive vaginal discharge， fever， and down-bearing pain in the lower abdomen) were compared between the two groups. Clinical effects and the incidence of adverse reactions were evaluated in the two groups. Results： The total effective rate was 80.85% in the control group，lower than that of 95.74% in the control group (P＜0.05). The disappearance time of lower abdominal pain， excessive vaginal discharge， fever， and down- bearing pain in the lower abdomen in the observation group was shorter than that in the control group (P＜0.05). TCM syndrome scores，pelvic fluid volume，CRP，WBC，NEUT，and the levels of serum miR-34a after treatment in the two groups were decreased when compared with those before treatment (P＜0.05)，and serum SIRT1 was increased (P＜0.05)；TCM syndrome scores，pelvic fluid volume，CRP，WBC，NEUT，and the levels of serum miR- 34a after treatment in the observation group were lower than those in the control group (P＜ 0.05)，and serum SIRT1 in the observation group was higher than that in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：Jingangteng Capsules combined with Cefoxitin Sodium Injection has a definite curative effect in the treatment of pelvic inflammatory disease and can reduce the level of serum miR-34 and inflammatory responses and increase SIRT1 level，with high safety.