Abstract：Objective：To observe the clinical effect of point injection of methylprednisolone combined with basic treatment on patients with acute severe asthma attack and the effects on their lung function and quality of life. Methods： A total of 80 cases of patients with acute severe asthma attack were selected as the study objects and divided into the control group and the trail group according to the random number table method，with 40 cases in each group. On the basis of maintaining the conventional Chinese and western medicine regimen， The control group additionally received intravenous injection of Methylprednisolone Sodium Succinate for Injection ，and the trial group was additionally treated with point injection of Methylprednisolone Sodium Succinate for Injection. Clinical effects and the incidence of adverse reactions were compared between the two groups. The lung function indicators and the scores of the Asthma Control Test (ACT) and St. George's Respiratory Questionnaire (SGRQ) were compared between the two groups before and after treatment. Results：The total effective rate was 95.00% in the trial group， higher than that of 80.00% in the control group (P＜0.05). After treatment，peak expiratory flow (PEF)，the forced expiratory volume in one second (FEV1)，and the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) in the two groups were increased (P＜0.05)，and the above three indexes in the trial group were higher than those in the control group (P＜0.05). After treatment，the SGRQ scores in the two groups were decreased (P＜0.05)，and the ACT scores were increased (P＜0.05)；the SGRQ score in the trial group was lower than that in the control group (P＜0.05)，and the ACT score in the trial group was higher than that in the control group (P＜0.05). The duration of asthma and hospitalization time in the trial group were shorter than those in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions (P＞0.05). Conclusion： For patients with acute severe asthma attack， point injection of methylprednisolone combined with basic treatment can enhance clinical effects， rapidly relieve the symptoms of acute attack， recover the lung function， and improve quality of life without any increase in adverse reactions.