Abstract：Guangdong- Hong Kong- Macao Greater Bay Area，a national development strategic area， has built an important promotion platform for the international communication of Chinese medicine with unique conditions. However， due to various factors， Chinese medicine in this region has its regional particularity of Lingnan Area，and there are also diversity and differences in the geographical，climatic and physiological conditions of people around the world. Therefore，it is necessary to rethink the difficulties and solutions that may be encountered in the international communication of Chinese medicine. By analyzing the advantages and disadvantages of international communication of Chinese medicine in Guangdong-Hong Kong-Macao Greater Bay Area，this paper proposes to promote the international communication of Chinese medicine in the Guangdong-Hong Kong-Macao Greater Bay Area from three aspects ： identification of Chinese medicine status，source- based communication and modern technology. It is hoped that this will be a breakthrough to face the possible problems in the international communication of Chinese medicine in a dynamic and personalized way.