Abstract：Objective：To observe the clinical effect of Jingu Tongxiao Pills combined with Celecoxib on knee osteoarthritis (KOA). Methods： A total of 86 cases of KOA patients were randomly divided into the study group and the control group， with 43 cases in each group. The control group was treated with Celecoxib，and the study group was additionally treated with Jingu Tongxiao Pills based on the treatment of the control group. After 2 months of medication， clinical effects were evaluated in the two groups； traditional Chinese medicine (TCM) syndrome scores，the Numerical Rating Scale (NRS)，maximum angles of knee joint flexion and extension， and the levels of interleukin- 1β (IL- 1β)， interleukin- 7 (IL- 7)， and fibroblast growth factor- 2 (FGF- 2) in serum were compared between the two groups before and after treatment. Results：After treatment，the total effective rate was 93.02% in the study group and 67.44% in the control group，the difference being significant (P＜0.05). After treatment，TCM syndrome scores and NRS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and TCM syndrome score and NRS score in the study group were lower than those in the control group (P＜ 0.05). After treatment，the levels of IL-1β and IL-7 in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of FGF- 2 were increased when compared with those before treatment (P＜0.05)；the levels of IL-1β and IL-7 in the study group were lower than those in the control group (P＜0.05)，and the level of FGF-2 in the study group was higher than that in the control group (P＜0.05). After treatment，the maximum angles of knee joint flexion and extension in the two groups were increased when compared with those before treatment (P＜0.05)，and the maximum angles of knee joint flexion and extension in the study group were larger than those in the control group (P＜0.05). Conclusion： Jingu Tongxiao Pills combined with Celecoxib have better curative effect than the simple application of Celecoxib in the treatment of KOA，and can significantly improve clinical symptoms，down- regulate the levels of inflammatory factors，and reduce joint damage.