Abstract：Objective：To explore the mechanism of Bazhen Decotion in remodeling esophageal cancer tumor microenvironment based on network pharmacology and bioinformatics. Methods： The active ingredients and targets of Bazhen Decotion were collected from the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP)， transcriptome data and clinical information of esophageal cancer patients were downloaded from the TCGA database，and stromal score，immune score and comprehensive score of esophageal cancer samples were calculated according to the ESTIMATE algorithm. To screen the genes related to the prognosis of esophageal cancer microenvironment，and use these genes as the relevant targets to reshape the esophageal cancer microenvironment. Finally，Chinese medicinals targets and disease targets were selected and combined to obtain the related targets of Bazhen Decoction in reshaping esophageal cancer microenvironment， and the "Chinese medicinals- ingredientstargets" network was constructed by Cytoscape 3.9.1. Construct protein- protein interaction (PPI) network based on STRING 11.5 database and Cytoscape 3.9.1 software， and screen core genes through CytoHubba， a plugin of Cytoscape 3.9.1. DAVID database was used to conduct gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for common targets of TCM and diseases，and molecular docking verification of drug active ingredients and core genes was carried out. Results： A total of 31 genes related to the remodeling of esophageal cancer tumor microenvironment by Bazhen Decoction were obtained， and the top 5 important genes were selected according to MCC algorithm： ICAM1， CCL2， CXCL10， STAT1 and VCAM1. GO function and KEGG pathway enrichment analysis showed that the common target genes of Chinese medicinals-diseases were mainly enriched in chemokine signaling pathway，TNF signaling pathway，NF-κB signaling pathway and so on. The results of molecular docking showed that the main active components of Bazhen Decoction had good binding force with the core target protein. Conclusion：Bazhen Decoction may regulate chemokine， TNF， NF- κB and other signaling pathways by targeting ICAM1， CCL2， CXCL10， STAT1， VCAM1 and other key genes to remodel the tumor microenvironment of esophageal cancer，thereby affecting the cell growth，invasion and metastasis，angiogenesis，and chemical drug resistance of esophageal cancer.