Abstract： Objective： To observe the curative effect of Kangfuxin Liquid combined with Omeprazole Enteric - Coated Capsules for duodenal ulcer. Methods： A total of 94 patients with duodenal ulcer were selected and divided into the control group and the observation group according to the random number table method， with 47 cases in each group. The control group was treated with Omeprazole Enteric-Coated Capsules， and the observation group was treated with Omeprazole Enteric-Coated Capsules combined with Kangfuxin Liquid. The clinical effects， incidence of adverse reactions and recurrence rates were compared between two groups，and the changes in symptom scores，inflammatory factors [hypersensitive C-reactive protein (hs-CRP)， interleukin-6 (IL-6)， and interleukin-8 (IL-8)]， gastric epidermal growth factor (EGF)， and Quality of Life Scale (SF-36) scores were compared in the two groups before and after treatment. Results： The total effective rate was 93.62% in the observation group， and 78.72% in the control group， the difference being significant (P＜0.05). After treatment， the scores of abdominal pain， acid reflux， and burning sensation in the two groups were decreased when compared with those before treatment， and the above three scores in the observation group were lower than those in the control group， differences being significant (P＜0.05). After treatment， the levels of hs-CRP， IL-6， and IL-8 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of hs-CRP，IL-6 and IL-8 in the observation group were lower than those in the control group (P＜0.05). After treatment， the EGF levels in the two groups were increased when compared with those before treatment (P＜0.05)， and the EGF level in the observation group was higher than that in the control group (P＜0.05). The incidence of adverse reactions was 8.51% in the observation group， and 12.77% in the control group，there being no significance in the difference (P＞0.05). After following up for 6 months， the recurrence rate was 9.09% in the observation group，and 32.43% in the control group，the difference being significant (P＜0.05). Conclusion： Kangfuxin Liquid combined with Omeprazole Enteric-Coated Capsules for duodenal ulcer can effectively improve the curative effect， clinical symptoms and quality of life，reduce inflammatory factor levels and recurrence，with good safety.