Abstract：Objective：To observe the clinical effect of the therapy of Xianling Gubao Capsules combined with Salmon Calcitonin on postmenopausal osteoporosis. Methods： A total of 120 patients with postmenopausal osteoporosis were divided into the control group and the observation group according to the random number table method， with 60 cases in each group. The control group was given Salmon Calcitonin for treatment， and the observation group was treated with Xianling Gubao Capsules combined with Salmon Calcitonin. Both groups were treated for three months. The traditional Chinese medicine (TCM) syndrome scores，scores of Short Form McGill Pain Questionnaire (SF-MPQ)，levels of bone metabolism indexes， including parathyroid hormone (PTH)， bone gamma-carboxyglutamate protein (BGP) and calcitonin (CT)，and the bone density of anterior position of lumbar spine (L1~L4)，femoral neck and Ward's triangle were compared before and after treatment between the two groups； the clinical effects and incidence of adverse reactions in both groups were evaluated. Results：After treatment，the total effective rate in the observation group was higher than that in the control group (P＜0.05). After treatment，the TCM syndrome scores， scores of each dimension in SF-MPQ and PTH levels in both groups were decreased when compared with those before treatment (P＜0.05)， the bone density of anterior position of lumbar spine (L1~L4)， femoral neck and Ward's triangle and the levels of BGP and CT were increased (P＜0.05)； the TCM syndrome score， scores of each dimension in SF-MPQ and PTH level in the observation group were lower than those in the control group (P＜0.05)，the bone density of anterior position of lumbar spine (L1~L4)，femoral neck and Ward's triangle，and the levels of BGP ，and CT were higher than those in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Xianling Gubao Capsules combined with Salmon Calcitonin has a definite curative effect on postmenopausal osteoporosis，which can effectively improve the levels of bone metabolism and bone density， and mitigate pain with good safety.