Abstract： Objective： To observe the clinical effect of the therapy of Huanglong Zhike Granules combined with aerosol inhalation with Budesonide on children with bronchial asthma. Methods： A total of 82 children with bronchial asthma were selected and divided into the control group and the observation group according to the random number table method. The control group was given routine treatment，and the observation group was additionally treated with Huanglong Zhike Granules combined with aerosol inhalation. The clinical effects， and indexes of inflammatory factors and immune function were compared between the two groups. Results：After one week of treatment，the total effective rate was 92.68% in the observation group， higher than that of 78.05% in the control group (P＜0.05). After treatment， the traditional Chinese medicine (TCM) syndrome scores in both groups were decreased (P＜0.05)， and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). After treatment，the scores of Children Asthma Control Test (C-ACT) in both groups were increased (P＜0.05)， and the C-ACT score in the observation group was higher than that in the control group (P＜0.05). After treatment，the forced expiratory volume in one second (FEV1)，forced vital capacity (FVC) and FEV1 /FVC in the observation group were increased (P＜0.05)，FEV1/FVC in the control group was increased (P＜0.05) and the FEV1，FVC and FEV1/FVC in the observation group were higher than those in the control group (P＜0.05). After treatment，the levels of serum hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in both groups were decreased (P＜0.05)， and the above levels in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of CD4+ and CD4+/CD8+ in the two groups were increased (P＜0.05)， and the CD8+ levels were decreased (P＜0.05)； the levels of CD4+ and CD4+/ CD8+ in the observation group were higher than those in the control group (P＜0.05)， and the CD8+ level was lower than that in the control group (P＜0.05). Conclusion：The therapy of Huanglong Zhike Granules combined with aerosol inhalation with Budesonide can effectively mitigate the clinical symptoms of children with bronchial asthma， and improve the lung function and clinical effect， whose mechanism may be related to that Huanglong Zhike Granules can adjust the inflammatory responses and immune responses of children with bronchial asthma and enhance the immune function.