Abstract： Objective： To observe the clinical effect of modified Xiaoke Preseription combined with Dapagliflozin for type 2 diabetes mellitus (T2DM) with deficiency of both qi and yin with stasis syndrome and its effects on the levels of white blood cell count (WBC) and C-reaction protein (CRP). Methods：A total of 102 cases of T2DM patients with deficiency of both qi and yin with stasis syndrome were selected and randomly divided into the observation group and the control group，with 51 cases in each group. The control group was treated with Dapagliflozin， and the observation group was additionally treated with modified Xiaoke Preseription based on the treatment of the control group. Both groups were treated for 2 months. Clinical effects， traditional Chinese medicine （TCM） syndrome scores， glucose metabolism indicators [fasting blood glucose (FBG)，2- hour postprandial blood glucose (P2hBG)]，pancreatic function indicators [fasting insulin (FINS)， insulin resistance index (HOMA- IR)]， inflammatory indicators (WBC， CRP)， and the incidence of adverse reactions were compared between the two groups. Results：After treatment，the total effective rate was 96.08% in the observation group，higher than that of 86.27% in the control group (P＜0.05). The scores of dry throat and mouth， fatigue and lack of strength， polyphagia with rapid hungering，and thirst with a desire to drink in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above four TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). The levels of FBG， P2hGB， FINS， and HOMA- IR in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of above four indicators in the observation group were lower than those in the control group (P＜0.05). The levels of WBC in peripheral blood and CRP in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of above two indexes in the observation group were lower than those in the control group (P＜0.05). During treatment，the incidence of adverse reactions was 7.84% in the observation group and 5.88% in the control group， and there was no significant difference in the comparison (P＞0.05). Conclusion：Modified Xiaoke Preseription combined with Dapagliflozin has a definite curative effect in the treatment of T2DM with deficiency of both qi and yin with stasis syndrome，and can relieve clinical symptoms， improve insulin resistance， and reduce the levels of blood glucose and inflammatory indicators.