Abstract： Objective： To observe the effect of therapy of comprehensive nursing combined with intervention of warming- needle moxibustion on cognitive function of patients with stroke based on the transtheoretical model. Methods：A total of 240 patients with stroke were selected as the study subjects and divided into the control group and the study group according to the random number table method，with 120 cases in each group. The control group was given rehabilitation therapy and routine nursing，and the study group was additionally treated with intervention of comprehensive nursing combined with warmingneedle moxibustion based on the transtheoretical model and the treatment of the control group. After 6 weeks of treatment， the compliance behavior， incidence of complications， and scores of Memory Quotient (MQ)， Mini- Mental State Examination (MMSE) and quality of life were compared between the two groups before and after intervention. Results： After treatment， the scores of diet， administratio of medicines，emotional management and exercises in the compliance behavior scale in the study group were significantly higher than those in the control group (P＜0.05). After treatment，the scores of MQ and MMSE in both groups were significantly increased when compared with those before treatment， and the above two scores in the study group were higher than those in the control group (P＜0.05). The incidence of hemiplegia，aspiration，fall and unplanned extubation was 0，3.33%，4.17% and 5.83%，respectively in the study group and 10.00% ， 15.83% ， 20.83% and 20.83% ， respectively in the control group， differences being significant (P＜0.05). After treatment， the scores of role- physical， social function and role- emotional in the quality of life scale in the two groups were increased when compared with those before treatment (P＜0.05)，and the above three scores in the study group were higher than those in the control group (P＜0.05). Conclusion：Based on the transtheoretical model，the therapy of comprehensive nursing combined with intervention of warming-needle moxibustion for stroke can significantly improve the cognitive function and therapy adherence of patients， enhance the quality of life and highly reduce the incidence of complications.