Clinical Study on Modified Shengmai San and Qianjin Weijing Decoction for Senile Patients with Severe Pneumonia of Phlegm-Heat Obstructing the Lung Type
Abstract: Objective: To observe the clinical effect of modified Shengmai San and Qianjin Weijing Decoction for senile patients with severe pneumonia of phlegm- heat obstructing the lung type. Methods: A total of 80 cases of senile patients with severe pneumonia of phlegm-heat obstructing the lung type were divided into the control group and the observation group according to the random number table method, with 40 cases in each group. The control group was given routine symptomatic treatment of western medicine, and the observation group was additionally treated with modified Shengmai San and Qianjin Weijing Decoction based on the treatment of the control group. Both groups were treated for 2 weeks. Traditional Chinese medicine (TCM) syndrome scores,Clinical Pulmonary Infection Scores (CPIS),Multiple Organ Dysfunction Syndrome (MODS) scores, Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ),lung function indexes [forced vital capacity (FVC),peak expiratory flow rate (PEF),forced expiratory (PCT),C- reactive protein (CRP),interleukin- 6 (IL- 6) in the two groups were compared before and after treatment. The clinical effects and the incidence of adverse reactions in the two groups were compared. Results:After treatment,the total effective rate was 92.50% in the observation group,higher than that of 75.00% in the control group (P<0.05). After treatment, TCM syndrome scores, CPIS scores, MODS scores,and APACHEⅡ scores,and the levels of WBC,PCT,CRP,and IL- 6 in the two groups were decreased when compared with those before treatment (P<0.05), and all the above scores and the inflammatory indexes in the observation group were lower than those in the control group (P<0.05). After treatment, the levels of FVC, PEF, FEV1, and FEV1/FVC in the two groups were increased when compared with those before treatment (P<0.05),the lung function indexes in the observation group were higher than those in the control group (P<0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P>0.05). Conclusion:Modified Shengmai San and Qianjin Weijing Decoction has a definite curative effect in treating senile patients with severe pneumonia of phlegm-heat obstructing the lung type,which can further relieve clinical symptoms, inhibit lung inflammation and improve lung function,with high safety.