Abstract：Objective：To observe the clinical effect of Moluo Pellets combined with quadruple therapy for Helicobacter pylori (Hp)-positive chronic atrophic gastritis (CAG) of stomach collateral stasis obstruction type. Methods： A total of 160 cases of patients with Hp- positive CAG of stomach collateral stasis obstruction type were selected as the study objects，and were divided into the study group and the control group according to the random number table method，with 80 cases in each group. The control group was treated with quadruple therapy ， and the study group was additionally given the oral administration of Moluo Pellets based on the treatment of the control group. The clinical effects of CAG in the two groups were observed ； the Hp negative conversion rates and the incidence of adverse reactions after treatment were compared between the two groups； the changes in contents of serum inflammatory factors [tumor necrosis factor- α (TNF- α)， interleukin- 1β (IL- 1β)， interleukin- 6 (IL- 6)， interleukin- 8 (IL- 8)]， gastrointestinal hormones [gastrin (GAS)， motilin (MTL)， somatostatin (SS)]， and pepsinogen [pepsinogen Ⅰ(PGⅠ) and pepsinogen Ⅱ (PGⅡ)] were compared before and after treatment between the two groups. Results：After treatment，the total effective rate was 96.25% in the study group and 78.75% in the control group， the difference being significant (P＜0.05). After treatment， the Hp negative conversion rate was 93.75% in the study group and 81.25% in the control group， the difference being significant (P＜0.05). After treatment， the levels of TNF- α，IL- 1β，IL- 6 and IL- 8 in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，the the above four levels in the study group were lower than those in the control group (P＜0.05). After treatment，the levels of GAS and SS in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and MTL levels were increased when compared with those before treatment (P＜0.05)；the levels of GAS and SS in serum in the study group were lower than those in the control group (P＜0.05)，and MTL level was higher than that in the control group (P＜0.05). After treatment，the contents of serum PGⅠ in the two groups were increased when compared with those before treatment (P＜0.05)，and PGⅡ contents were not significantly different from those before treatment (P＞0.05)；the content of serum PGⅠ in the study group was higher than that in the control group (P＜0.05)，PGⅡ content was not significantly different from that in the control group (P＞0.05). During treatment，the incidence of adverse reactions was 11.25% in the study group and 8.75% in the control group，there being no significant difference between the two groups (P＞0.05). Conclusion： Moluo Pellets combined with quadruple therapy for Hp- positive CAG of stomach collateral stasis obstruction type can effectively improve the clinical effect，enhance the clearance effect of Hp， relieve inflammation， and improve the secretion of gastrointestinal hormones and pepsinogen， without increasing the risk of medication.