补肝强腰方联合射频消融术治疗腰椎间盘突出症临床研究
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R687.3

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东阳市科技计划项目(21-301)


Clinical Study on Bugan Qiangyao Prescription Combined with Radiofrequency Ablation for Lumbar Disc Herniation
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    摘要:

    目的:观察补肝强腰方联合射频消融术治疗腰椎间盘突出症(LDH) 的临床疗效及对炎症因子的 影响。方法:采用随机数字表法将124 例LDH 患者分为对照组与观察组各62 例。对照组行射频消融术治疗, 观察组在对照组基础上加用补肝强腰方治疗,2 组均治疗8 周。比较2 组中医证候积分、视觉模拟评分 法(VAS)、日本骨科协会评估量表(JOA) 评分及血清炎症因子[肿瘤坏死因子-α (TNF-α)、白细胞介 素(IL) -1β、IL-6] 水平,评估2 组临床疗效及不良反应发生情况。结果:观察组总有效率95.16%,高于对 照组82.26%(P<0.05)。治疗后,2 组中医证候积分、VAS 评分及血清TNF-α、IL-1β、IL-6 水平均较治疗前 降低(P>0.05),JOA 评分升高(P<0.05),且观察组中医证候积分、VAS 评分及血清炎症因子水平低于对照 组(P<0.05),JOA 评分高于对照组(P<0.05)。观察组与对照组不良反应发生率比较,差异无统计学意 义(P>0.05)。结论:补肝强腰方联合射频消融术治疗LDH 疗效确切,能够减轻患者疼痛,改善腰椎功能, 抑制炎症反应,安全性较高。

    Abstract:

    Abstract: Objective: To observe the clinical effect of the therapy of Bugan Qiangyao Prescription combined with radiofrequency ablation on the lumbar disc herniation (LDH) and its effect on inflammatory factors. Methods:A total of 124 cases patients with LDH were divided into control group and observation group by random number table method. The control group was given with radiofrequency ablation,and the observation group was additionally given Bugan Qiangyao Prescription based on the treatment of the control group. The two groups were treated for 8 weeks. The traditional Chinese medicine (TCM) syndrome scores,scores of Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA),and levels of serum inflammatory factors,including tumor necrosis factor-α (TNF-α),interleukin(IL)-1β and IL-6 were compared between the two groups;the clinical effects and incidence of side reactions in two groups were compared. Results:The total effective rate was 95.16% in observation group,higher than that of 82.26% in control group (P<0.05). After treatment, the TCM syndrome scores, VAS scores and the levels of serum TNF- α, IL- 1β and IL- 6 in both groups were all decreased when compared with those before treatment (P<0.05), and the JOA scores were increased (P<0.05); the TCM syndrome scores, VAS scores and the levels of serum TNF- α,IL- 1β and IL- 6 in observation group were lower (P<0.05),and the JOA score was higher than that in the control group (P<0.05). The incidence of side reactions was not significant in observation group and in control group (P>0.05). Conclusion:The therapy of Bugan Qiangyao Prescription combined with radiofrequency ablation has a definite curative effect on LDH, which can mitigate the pain,improve the lumbar vertebral function and inhibit the inflammatory responses with good safety.

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杨俊涛,罗玉雷,陈叶海.补肝强腰方联合射频消融术治疗腰椎间盘突出症临床研究[J].新中医,2024,56(3):64-67

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  • 在线发布日期: 2024-02-23
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