Abstract： Objective： To observe the clinical effect of the therapy of Bugan Qiangyao Prescription combined with radiofrequency ablation on the lumbar disc herniation (LDH) and its effect on inflammatory factors. Methods：A total of 124 cases patients with LDH were divided into control group and observation group by random number table method. The control group was given with radiofrequency ablation，and the observation group was additionally given Bugan Qiangyao Prescription based on the treatment of the control group. The two groups were treated for 8 weeks. The traditional Chinese medicine (TCM) syndrome scores，scores of Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA)，and levels of serum inflammatory factors，including tumor necrosis factor-α (TNF-α)，interleukin(IL)-1β and IL-6 were compared between the two groups；the clinical effects and incidence of side reactions in two groups were compared. Results：The total effective rate was 95.16% in observation group，higher than that of 82.26% in control group (P＜0.05). After treatment， the TCM syndrome scores， VAS scores and the levels of serum TNF- α， IL- 1β and IL- 6 in both groups were all decreased when compared with those before treatment (P＜0.05)， and the JOA scores were increased (P＜0.05)； the TCM syndrome scores， VAS scores and the levels of serum TNF- α，IL- 1β and IL- 6 in observation group were lower (P＜0.05)，and the JOA score was higher than that in the control group (P＜0.05). The incidence of side reactions was not significant in observation group and in control group (P＞0.05). Conclusion：The therapy of Bugan Qiangyao Prescription combined with radiofrequency ablation has a definite curative effect on LDH， which can mitigate the pain，improve the lumbar vertebral function and inhibit the inflammatory responses with good safety.