Abstract： Objective： To observe the clinical effect of Neiyi Prescription combined with Mifepristone Tablets for endometriosis (EMT). Methods：A total of 108 cases of EMT patients were selected as the study objects and divided into the control group and the observation group according to the random number table method，with 54 cases in each group. The control group was treated with Mifepristone Tablets，and the observation group was additionally treated with Neiyi Prescription based on the treatment of the control group. Both groups were treated for three menstrual cycles. Traditional Chinese medicine syndrome scores， pain mediators， blood viscosity and serum- related factors were compared before and after treatment between the two groups. Results： After treatment， the scores of lower abdominal distension pain， scanty menstruation and menstrual blood clots in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of nerve growth factor (NGF)， prostaglandin F2α (PGF2α)，and prostaglandin E2 (PGE2) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of NGF，PGF2α and PGE2 in the observation group were lower than those in the control group (P＜0.05). After treatment，the plasma viscosity，high- shear whole blood viscosity and low- shear whole blood viscosity in the two groups were decreased when compared with those before treatment (P＜0.05)， and the plasma viscosity， high- shear whole blood viscosity and low- shear whole blood viscosity in the observation group were lower than those in the control group (P＜0.05). After treatment， the levels of retinol- binding protein 4 (RBP4)， monocyte chemoattractant protein 1 (MCP- 1) and intercellular adhesion related factor (ICAM- 1) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of RBP4， MCP- 1 and ICAM- 1 in serum in the observation group were lower than those in the control group (P＜ 0.05). Conclusion： Neiyi Prescription can improve the clinical symptoms of patients with EMT， regulate pain mediators and blood viscosity，and regulate the levels of serum-related factors.