Abstract：Objective：To observe the effect of transcutaneous auricular vagus nerve stimulation (taVNS) with auricular point seed-pressing on patients with post-stroke cognitive dysfunction (PSCI). Methods：A total of 84 PSCI patients were selected and divided into the intervention group and the control group according to the random number table method，with 42 cases in each group. The two groups were treated with basic medicine and cognitive rehabilitation training； the intervention group was additionally given auricular points of heart and kidney seed- pressing，and the control group was additionally given auricular points of elbow and shoulder seed- pressing. The two groups were treated for 12 weeks. The changes of scores of Mini- Mental State Examination (MMSE)， Montreal Cognitive Assessment (MoCA)， Modified Barthel Index (MBI) and Neuropsychiatric Inventory (NPI) were compared before and after treatment between the two groups. Results： After treatment， the scores of MMSE and MoCA in the two groups were increased when compared with those before treatment (P＜0.05)， and the above scores in the intervention group were higher than those in the control group (P＜0.05). After treatment，the MBI scores in the two groups were increased when compared with those before treatment (P＜0.05)， the scores of NPI-1 and NPI-2 were decreased when compared with those before treatment (P＜0.05)；the MBI score in the intervention group was higher than that in the control group， there being no significance in the difference (P＞0.05)；the scores of NPI-1 and NPI-2 in the intervention group were lower than those in the control group (P＜0.05). Conclusion：The taVNS with auricular point seed-pressing can improve the global cognitive function and neuropsychiatric symptoms of PSCI patients and reduce the anxiety of caregivers.