Abstract：Objective：To observe the clinical effect of Ercao Qinggan Mixture combined with Polyene Phosphatidylcholine Capsules for nonalcoholic fatty liver disease (NAFLD) with damp- heat accumulation syndrome. Methods：A total of 104 cases of NAFLD patients with damp-heat accumulation syndrome were selected and divided into the control group and the treatment group according to the random number table method， with 52 cases in each group. The control group was treated with Polyene Phosphatidylcholine Capsules， and the treatment group was additionally treated with Ercao Qinggan Mixture based on the treatment of the control group. Both groups were treated for 3 months. The clinical effects， biochemical indexes， traditional Chinese medicine (TCM) syndrome scores and oxidative stress indexes were compared between the two groups. Results：After treatment，the total effective rate was 94.23% in the treatment group， higher than that of 78.85% in the control group， the difference being significant (P＜ 0.05). The levels of aspartate aminotransferase (AST)， alanine aminotransferase (ALT)， total cholesterol (TC)，and triglyceride (TG) in serum in the two groups were decreased when compared with those before treatment，and the above four levels in the treatment group were lower than those in the control group， differences being significant (P＜0.05). The TCM syndrome scores in the two groups were decreased when compared with those before treatment，and the TCM score in the treatment group was lower than that in the control group， differences being significant (P＜0.05). The levels of pentraxin 3 (PTX3)， superoxide dismutase (SOD) and glutathione peroxidase (GSH- Px) in serum in the two groups were increased when compared with those before treatment，and the above three levels in the treatment group were higher than those in the control group， differences being significant (P＜0.05). Conclusion： Ercao Qinggan Mixture combined with Polyene Phosphatidylcholine Capsules for NAFLD with damp- heat accumulation syndrome can relieve clinical symptoms，improve liver function，and regulate blood lipid levels and oxidative stress reactions.