Abstract：Objective：To observe the clinical effect of the therapy of Babaodan Capsules combined with western medicine on acute icteric hepatitis of damp- heat accumulation type. Methods ： A total of 220 patients with acute icteric hepatitis of damp- heat accumulation type were selected as the study subjects and divided into the study group and the control group according to the random number table method，with 110 cases in each group. The two groups were given western medicines for antiviral，antiinflammation， hepatoprotection，reducing enzyme，and treating jaundice and cholagogue，and the study group was additionally treated with Babaodan Capsules. The two groups were treated for 4 weeks. Before and after treatment， the traditional Chinese medicine (TCM) syndrome scores were evaluated； the levels of liver function indexes were detected， including aspartate aminotransferase (AST)， alanine aminotransferase (ALT)，γ-glutamyl transferase (γ-GT)，total bile acid (TBA) and total bilirubin (TBil)；the clinical effects， curative effects of TCM syndromes and incidence of adverse reactions were compared between the two groups. Results：After treatment，the total clinical effective rate and total effective rate of TCM syndromes in the study group were higher than those in the control group (P＜0.05). The levels of AST， ALT， γ- GT， TBA and TBil in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above levels in the study group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The therapy of Babaodan Capsules combined with western medicine can enhance the clinical effect on acute icteric hepatitis of damp-heat accumulation type， mitigate the symptoms， and promote the recovery of liver function with no increase in the medication safety risks.