儿童急性喉炎中医证素及发生喉梗阻危险因素相关性分析
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Correlation Analysis of Traditional Chinese Medicine Syndrome Elements and Risk Factors of Laryngeal Obstruction in Children with Acute Laryngitis
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    摘要:

    目的:探讨儿童急性喉炎的中医证素及儿童急性喉炎发生喉梗阻危险因素的相关性分析。方法: 收集2011 年8 月—2023 年4 月在广州中医药大学第一附属医院儿科住院治疗的255 例急性喉炎患儿的病历资 料(基本资料、四诊信息、白细胞数值、喉梗阻情况等),采取证素辨证法确定中医证素,将结果导入SPSS Modeler18.0 软件,采用Apriori 算法进行关联规则分析,证素之间的关系以复杂网络图表示,采取系统聚类分 析法分析不同证素组合情况,并将相关因素进行二元Logistic 回归分析。结果:共纳入255 例患儿,其中以婴 幼儿居多。255 例患儿共提取证素14 个,包括病位证素4 个和病性证素10 个。病位证素为肺、表、心神、小 肠,病性证素中热、外风、痰为高频证素,证素组合以肺+表+热+外风占比最高。证素组成以肺、表、热为中 心,形成了肺-热、表-肺、表-热、外风-肺、外风-表、外风-热、肺-痰、热-痰8 组强链接。取类间距为 24,可取得2 个聚类单元,其中病位证素肺、表与病性证素热、血热、外风、痰、饮、寒为一类,病位证素心 神、小肠与病性证素毒、闭、动风、湿为一类。证素饮对急性喉炎患儿发生喉梗阻的影响有统计学意义(P< 0.05)。证素表、外风、闭、血热及白细胞增高对急性喉炎患儿发生喉梗阻的影响无统计学意义(P>0.05)。 结论:儿童急性喉炎发病是因风热、风寒之邪侵犯肺脏或痰热壅盛,阻遏肺气,肺失宣降,声门开阖不利所 致。证素饮是急性喉炎患儿发生喉梗阻的危险因素。

    Abstract:

    Abstract: Objective: To explore the correlation analysis of traditional Chinese medicine (TCM) syndrome elements and correlation analysis of risk factors for the development of laryngeal obstruction in children with acute laryngitis. Methods: Medical records of 255 cases of children with acute laryngitis hospitalized in the Department of Pediatrics of The First Affiliated Hospital of Guangzhou University of Chinese Medicine from August 2011 to April 2023 were collected (basic data, the four examinations, leukocyte counts, laryngeal obstruction, etc.). TCM syndrome elements were determined based on syndrome differentiation, and the results were imported into SPSS Modeler 18.0 software. The Apriori algorithm was used to analyze the association rules,and the relationship among them was represented by complex network diagram. The combination of different syndrome elements was analyzed by systematic cluster analysis,and the related factors were analyzed by binary logistic regression. Results:A total of 255 cases of children were included, most of whom were infants. A total of 14 syndrome elements were extracted from 255 cases of children; there were 4 syndrome elements on location of disease, namely lung,exterior,heart spirit and small intestine;there were 10 syndrome elements on nature of disease, among which heat, external wind and phlegm had high frequency, and the combination of syndrome elements with lung, exterior, heat and external wind accounted for the highest proportion. The composition of syndrome elements centered on lung,exterior and heat,and formed eight strong links of lung- heat,exterior- lung,exterior- heat,external wind- lung,external wind- exterior,external windheat, lung- phlegm, and heat- phlegm. With a class interval of 24, 2 cluster units could be obtained, among which the syndrome elements on location of disease like lung and exterior and the syndrome elements on nature of disease like heat,blood heat,external wind,phlegm,fluid retention and cold were classified as one class, while the syndrome elements on location of disease like heart spirit and small intestine and the syndrome elements on nature of disease like toxin,block,stirring wind and dampness were classified as one class. The effect of fluid retention syndrome element on the occurrence of laryngeal obstruction in children with acute laryngitis was statistically significant (P<0.05). There was no significant difference in the effects of exterior, external wind, block, blood heat and leukocyte increase on the occurrence of laryngeal obstruction in children with acute laryngitis (P>0.05). Conclusion:The incidence of acute laryngitis in children is caused by the pathogen of wind heat and wind cold invading the lung or excessive phlegm-heat obstructing lung qi,lung failing to diffuse and govern descent,as well as inhibited opening and closing of glottis. It can be seen that fluid retention syndrome element is a risk factor for laryngeal obstruction in children with acute laryngitis.

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谢美玉,王浩,黄钢花.儿童急性喉炎中医证素及发生喉梗阻危险因素相关性分析[J].新中医,2024,56(4):92-97

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  • 在线发布日期: 2024-02-28
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