Abstract：Objective：To observe the clinical effect of ultrasonic drug penetration therapy at points on chronic obstructive pulmonary disease (COPD) in stable stage. Methods：A total of 100 patients with COPD in stable stage were selected and divided into the control group and the observation group according to the random number table method， with 50 cases in each group. The control group was given Ipratropium Bromide Aerosol and Salbutamol Sulfate Aerosol for treatment，and the observation group was additionally given ultrasonic drug penetration therapy at acupoints of Baoyuan Bufei Prescription based on the treatment of the control group. The clinical effects，traditional Chinese medicine (TCM) syndrome scores，levels of lung function indexes，including forced expiratory volume at first second (FEV1)，FEV1/forced vital capacity (FEV1/FVC)，and peak expiratory flow (PEF)，scores of St George's Respiratory Questionnaire (SGRQ) and incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 96.00% in the observation group and 84.00% in the control group，the difference being significant (P＜ 0.05). After treatment，the TCM syndrome scores of primary and secondary symptoms and the total scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of FEV1， FEV1/FVC and PEF in the two groups were increased when compared with those before treatment (P＜0.05)，and the above levels in the observation group were higher than those in the control group (P＜0.05). After treatment， each score in the SGRQ and the total scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the observation group were lower than those in the control group (P＜0.05). During treatment， there was no significant adverse reaction in the two groups. Conclusion： The adoption of western medicines combined with ultrasonic drug penetration therapy at acupoints of Baoyuan Bufei Prescription can help improve the TCM syndromes，lung function and quality of life of patients with COPD in stable stage.