Abstract：Objective：To observe the clinical effect of point application combined with moxibustion for chronic superficial gastritis (CSG) and its effect on gastrointestinal hormones. Methods：A total of 100 cases of CSG patients were selected and divided into the observation group and the control group according to the random number table method， with 50 cases in each group. The control group was treated with Omeprazole Enteric-Coated Capsules combined with moxibustion，and the observation group was treated with acupoint application on the basis of the control group. Clinical effects， traditional Chinese medicine (TCM) syndrome scores， the levels of gastrointestinal hormones [gastrin (GAS)， somatostatin (SS)， and motilin (MLT)]， and adverse reactions were compared between the two groups. Results： The total effective rate was 86.00% in the observation group and 68.00% in the control group，the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of TCM syndrome scores of stomachache， reduced food intake， nausea and vomiting， sighing， belching，and acid swallowing between the two groups (P＞0.05)；after treatment，the above scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and each score in the observation group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of GAS，SS，and MLT in serum between the two groups (P＞0.05). After treatment，GAS levels in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of SS and MLT were increased when compared with those before treatment (P＜0.05)； GAS level in the observation group was lower than that in the control group (P＜0.05)， and the levels of SS and MLT in the observation group were higher than those in the control group (P＜0.05). During treatment， there were no obvious adverse reactions in the two groups. Conclusion：Point application combined with moxibustion has a definite curative effect in the treatment of CSG，which can effectively improve TCM syndromes and the levels of gastrointestinal hormones with good treatment safety.