Abstract: Objective: To screen the particle forming process of Jinbei Sanjie Granules. Methods: Under the premise of single factor investigation, orthogonal test was used, and paste to excipients, excipient A (soluble starch) to excipient B (powdered sugar), ethanol concentration and ethanol dosage (ethanol weight to excipient weight) were considered as factors. The four- factor and three- level L9(43) orthogonal test was carried out. The forming rate, angle of rest and bulk density were considered as indicators, and the optimal granulation process was initially screened by multi- index weighted scoring method. Results: The optimal granulation process was determined as paste to auxiliary material =1∶ 3, Soluble starch to powdered sugar = 1∶1,95% ethanol dosage was 5% of excipients. Conclusion:The optimized granulation process has high forming rate,uniform particles,good fluidity and good stability. The particle size and solubility meet the requirements,so the optimal process is reasonable and feasible.