Abstract： Objective： To screen the particle forming process of Jinbei Sanjie Granules. Methods： Under the premise of single factor investigation， orthogonal test was used， and paste to excipients， excipient A (soluble starch) to excipient B (powdered sugar)， ethanol concentration and ethanol dosage (ethanol weight to excipient weight) were considered as factors. The four- factor and three- level L9(43) orthogonal test was carried out. The forming rate， angle of rest and bulk density were considered as indicators， and the optimal granulation process was initially screened by multi- index weighted scoring method. Results： The optimal granulation process was determined as paste to auxiliary material =1∶ 3， Soluble starch to powdered sugar = 1∶1，95% ethanol dosage was 5% of excipients. Conclusion：The optimized granulation process has high forming rate，uniform particles，good fluidity and good stability. The particle size and solubility meet the requirements，so the optimal process is reasonable and feasible.