Abstract： This paper is to introduce Professor WANG Bangcai's clinical experience in treating the sequelae of novel coronavirus infection from five zang-organs based on syndrome differentiation. Professor WANG believes that there are different degrees of sequelae left after the novel coronavirus infection，such as cough，chest tightness，headache，fatigue，continuous low fever，and anxiety and depression. The important pathogenesis is “Lingering pathogen in the deficient locations imposes negative effect on the five- zang organs”. The principle of treatment is to reinforce the healthy qi and eliminate the pathogenic factors from the five- zang organs of the lung， heart， spleen， liver and kidney based on syndrome differentiation. The reinforcement of healthy qi should be according to the depletion degree of the affected viscera and bowels，qi and blood，and yin and yang by replenishing qi and nourishing yin，or warming yang and supplementing deficiency or tonifying both qi and blood；the elimination of pathogenic factors should be based on the nature of lingering pathogen by dispelling wind and dissipating cold，or clearing heat and resolving phlegm，or resolving dampness and detoxification，or detoxification and harmonizing the nutrient.