Abstract：Objective：To observe the clinical effect of modified Guizhi Fuling Decoction combined with acupuncture on senile patients in stroke recovery period. Methods：A total of 60 cases of senile patients in stroke recovery period were divided into the observation group and the control group according to the random number table method， with 30 cases in each group. Both groups were given routine basic treatment； the observation group was treated with modified Guizhi Fuling Decoction combined with acupuncture， and the control group was simply treated with acupuncture. The clinical effects were compared between the two groups；the scores of degree of neurological impairment，cognitive function and limb motor function were compared between the two groups；the levels of intracranial hemodynamics and inflammatory factors were compared between the two groups. Results： After treatment， the total effective rate was 93.33% in the observation group，higher than that of 73.33% in the control group (P＜ 0.05). After treatment， National Institutes of Health Stroke Scale (NIHSS) scores in the two groups were decreased (P＜0.05)，and the score in the observation group was lower than that in the control group (P＜ 0.05)， the scores of Mini- mental State Examination (MMSE) and Fugl- Meyer Assessment (FMA) in the two groups were increased (P＜0.05)，and the scores in the observation group were higher than those in the control group (P＜0.05). After treatment， the blood flow velocity of intracranial basilar artery (VBA)， anterior cerebral artery (ACA)，middle cerebral artery (MCA) and posterior cerebral artery (PCA) in the two groups were increased (P＜0.05)，and the blood flow velocity in the observation group was higher than that in the control group (P＜0.05). After treatment， the levels of tumor necrosis factor- α (TNF- α) and interleukin- 6 (IL- 6) in serum in the two groups were decreased (P＜0.05)， and the levels of serum interleukin-10 (IL-10) in the two groups were increased (P＜0.05)，and the level in the observation group was higher than that in the control group (P＜0.05). Conclusion：The application of modified Guizhi Fuling Decoction combined with acupuncture for senile patients with stroke can enhance the clinical effect， improve the neurological function， cognitive function and limb motor function， increase the intracranial blood flow velocity，and reduce the body inflammation.