Abstract：Objective：To observe the clinical effect of Qili Qiangxin Capsules combined with western medicine on chronic heart failure with yang deficiency and water retention syndrome. Methods：A total of 96 cases of patients with chronic heart failure with yang deficiency and water retention syndrome were divided into the observation group and the control group according to the random number table method， with 48 cases in each group. The control group was treated with routine western medicine， and the observation group was additionally treated with Qili Qiangxin Capsules based on the treatment of the control group. Both groups were treated for 3 months. The heart function indexes [left ventricular ejection fraction (LVEF)， left ventricular end- diastolic diameter (LVEDD)， left ventricular end- systolic diameter (LVESD)， the ratio of peak blood flow velocity (peak E) at the early stage of ventricular filling in bicuspid to peak atrial systolic blood flow velocity (peak A) at the late stage of ventricular filling (E/A)]，traditional Chinese Medicine (TCM) syndrome scores，Minnesota Living with Heart Failure Questionnaire (MLHFQ)，Six- minute Walk Test (6MWT)，and the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) were compared before and after treatment between the two groups； clinical effects and incidence of adverse reactions in the two groups were evaluated. Results： The total effective rate was 93.75% in the observation group and 70.83% in the control group， the difference being significant (P＜ 0.05). After treatment， TCM syndrome scores， MLHFQ scores， LVEDD， LVESD， and the levels of NT-proBNP and BNP in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and LVEF，E/A and 6MWT were increased (P＜0.05). After treatment，LVEF，E/A and 6MWT in the observation group were higher than those in the control group (P＜0.05)， and TCM syndrome score， MLHFQ score， LVEDD， LVESD， and the levels of NT- proBNP and BNP were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 4.17% in the control group and 2.08% in the observation group， there being no significant difference between the two groups (P＞0.05). Conclusion： Qili Qiangxin Capsules combined with western medicine for chronic heart failure with yang deficiency and water retention syndrome can improve heart function of patients and quality of life，with a significant clinical effect and high safety.