Abstract： Objective： To observe the effects of Xuantong Xuanfu Decoction combined with tongue cluster needling movement acupuncture method on expression ability，remote lesions and repair of central injury in patients with post- stroke aphasia. Methods： A total of 90 cases of patients with post- stroke aphasia were selected and divided into the acupuncture group and the study group according to the random number table method， with 45 cases in each group. Both groups were given basic treatment； the acupuncture group was additionally treated with tongue cluster needling movement acupuncture method， and the study group was additionally treated with Xuantong Xuanfu Decoction based on the treatment of the acupuncture group. The clinical effects in the two groups were evaluated； Chinese Functional Communication Profile (CFCP) and Chinese Rehabilitation Research Center Aphasia Examination (CRRCAE) were used to evaluate the language expression ability of the patients；traditional Chinese medicine (TCM) syndrome scores were counted； the levels of S100 calcin- binding protein B (S100B)， calcitonin generelated peptide (CCRP)， nerve growth factor (NGF)， K index of erythrocyte sedimentation equation， plasma viscosity， red blood cell aggregation indexes and hematocrit were compared before and after treatment between the two groups； the changes in FA values of infarct lesions and bilateral cerebral peduncle in the two groups were detected. Results： The total effective rate was 97.78% in the study group， higher than that of 82.22% in the acupuncture group (P＜0.05). After treatment， the scores of CFCP and CRRCAE in the two groups were increased when compared with those before treatment (P＜ 0.05)，and the scores in the study group were higher than those in the acupuncture group (P＜0.05). After treatment， TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and TCM syndrome scores in the study group were lower than those in the acupuncture group (P＜0.05). After treatment， S100B levels in the two groups were decreased when compared with those before treatment， and S100B level in the study group was lower than that in the acupuncture group (P＜0.05). The levels of CCRP and NGF in the two groups were increased when compared with those before treatment，and the levels of CCRP and NGF in the study group were higher than those in the acupuncture group (P＜0.05). After treatment， the K indexes of ESR equation， plasma viscosity， erythrocyte aggregation indexes and hematocrit in the two groups were decreased when compared with those before treatment (P＜0.05)， and the K index of ESR equation， plasma viscosity， erythrocyte aggregation index and hematocrit in the study group were lower than those in the acupuncture group (P＜0.05). After treatment，the FA values of infarct lesions and infarct ipsilateral cerebral peduncle in the two groups were decreased when compared with those before treatment (P＜0.05)；but the FA values of infarct lesions and infarct ipsilateral cerebral peduncle in the study group were higher than those in the acupuncture group (P＜0.05). Conclusion： Xuantong Xuanfu Decoction combined with tongue cluster needling movement acupuncture method for patients with post- stroke aphasia can promote the repair of central injury，improve hemorheology，reduce remote lesions，improve the expression ability of patients， and enhance clinical effects.