Abstract： Objective： To observe the clinical effect of acupuncture combined with Bufei Qiangxin Prescription on pulmonary heart disease with heart- lung qi deficiency syndrome. Methods： A total of 129 cases of patients with pulmonary heart disease with heart- lung qi deficiency syndrome were divided into the acupuncture group，the Chinese medicine group and the combination group，with 43 cases in each group. All the three groups were treated with routine western medicine； the acupuncture group was additionally treated with acupuncture， the Chinese medicine group was additionally treated with Bufei Qiangxin Prescription，and the combination group was additionally treated with acupuncture combined with Bufei Qiangxin Prescription. All the three groups were treated for 4 weeks. Traditional Chinese medicine (TCM) syndrome scores，six- minute walking test (6MWT），modified Medical Research Council (mMRC) scores，and Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores were compared before and after treatment among the three groups; lung function indexes [(peak expiratory flow rate (PEF)， forced expiratory volume in the first second (FEV1)，forced vital capacity (FVC)，ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC)，heart function indexes left ventricular ejection fraction (LVEF)，left ventricular end-diastolic diameter (LVEDD)，left ventricular end-systolic dimension (LVESD)， cardiac artery acceleration time (AT)]， and blood gas indexes [arterial oxygen partial pressure (PaO2)， oxygen saturation (SaO2)，carbon dioxide partial pressure (PaCO2)，hydrogen ion concentration index (pH)] before and after treatment were compared among the three groups；the clinical effects and the incidence of adverse reactions in the three groups were evaluated. Results：The total effective rate was 97.67% in the combination group，higher than that of 81.40% in the acupuncture group and 76.74% in the Chinese medicine group (P＜0.05). After treatment， mMRC， MLHFQ scores， TCM syndrome scores， LVEDD， LVESD，and PaCO2 in the three groups were decreased when compared with those before treatment (P＜ 0.05)，and the above indexes in the combination group were lower than those in the acupuncture group and the Chinese medicine group (P＜0.05). After treatment， 6MWT， PEF， FEV1， FVC， LVEF， PaO2， SV、 SaO2， and FEV1/FVC in the three groups and the values of pH in the combination group were increased when compared with those before treatment (P＜0.05)，and the above indexes in the combination group were higher than those in the acupuncture group and the Chinese medicine group (P＜0.05). No adverse reaction occurred in the two groups. Conclusion：Acupuncture combined with Bufei Qiangxin Prescription for pulmonary heart disease with heart-lung qi deficiency syndrome can improve cardiopulmonary function and blood gas indexes and enhance the quality of life，with high safety.