Abstract： Objective： To observe the effect of Chinese medicine point massage on developmental retardation in children. Methods：A total of 2 000 children with developmental retardation were selected and divided into the study group and the routine group according to the random number table method， with 1 000 cases in each group. In the study group， 48 cases fell off during treatment， and 952 cases were finally included. In the routine group， 51 cases fell off during treatment， and 949 cases were finally included. The routine group was given routine rehabilitation treatment，and the study group was additionally treated with Chinese medicine point massage based on the treatment of the control group. The changes in IQ development，language function [Gesell Development Schedule (GDS)]，motor function [Peabody Fine Motor Development Motor Scale (PDM- FM)， and Gross Motor Function Measure (GMFM)]， activity of daily living (ADL)，and brain nerve injury-related indexes [S100β protein，myelin basic protein (MBP)，and neuron-specific enolization (NSE)] were compared between the two groups. Results：After 3 and 6 months of treatment，the scores of language quotient，operation quotient and total intelligence quotient in the two groups were increased when compared with those before treatment， and the above three scores in the study group were higher than those in the routine group (P＜0.05). After 6 months of treatment，the scores of language quotient，operation quotient and total intelligence quotient in the two groups were increased when compared with those after 3 months of treatment (P＜0.05). After 3 and 6 months of treatment，the scores of grasping energy range， visual motor integration energy range， GMFM， and GDS in the two groups were increased when compared with those before treatment， and the above four scores in the study group were higher than those in the routine group (P＜0.05). After 6 months of treatment，the scores of grasping energy range， visual motor integration energy range， GMFM， and GDS in the two groups were increased when compared with those after 3 months of treatment (P＜0.05). After 3 and 6 months of treatment，the scores of Physical Self-Maintenance Scale，Instrumental Activities of Daily Living Scale and the total scores of ADL in the two groups were decreased when compared with those before treatment， and the above three scores in the study group were lower than those in the routine group (P＜0.05). After 6 months of treatment， the scores of Physical Self- Maintenance Scale， Instrumental Activities of Daily Living Scale and the total scores of ADL in the two groups were decreased when compared with those after 3 months of treatment (P＜0.05)，and the above three scores in the study group were lower than those in the routine group. After 3 and 6 months of treatment，the levels of S100β protein，MBP and NSE in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three levels in the study group were lower than those in the routine group (P＜0.05). After 6 months of treatment， the levels of S100 β protein ， MBP and NSE in the two groups were decreased when compared with those after 3 months of treatment (P＜0.05). Conclusion： Chinese medicine point massage has a significant effect in the treatment and rehabilitation of children with developmental retardation， which can relieve the brain nerve injury， promote the intellectual development of children， improve the language and motor function of children，and enhance their activities of daily living.