Abstract： Proteinuria is a common clinical symptom of chronic nephritis syndrome， which seriously affects the health and quality of life of patients. Professor ZHANG Min believes that spleen and kidney deficiency is the fundamental pathogenesis of proteinuria， blood stasis is the pathogenic factor of proteinuria， and "deficiency， dampness， and heat" are common pathological factors causing stasis. Professor ZHANG's clinical approach is to use a self-made Xiaodanbai Prescription as the main prescription for modified treatment， advocating staged treatment and integrating the concept of treating stasis throughout the entire treatment process. Professor ZHANG holds that，in the early stage，the spleen and kidney deficiency lasts long and results in stasis， and the treatment should focus on supplementing and benefiting the spleen and kidney， replenishing qi， and activating blood； in the middle stage， the deficiency accumulates for a long time and promote the generation of dampness，and dampness turbidity obstructs the vessels and collaterals， which can be treated with methods of dispelling wind， removing dampness，promoting blood circulation，and removing blood stasis；in the late stage，due to dampness， stasis，and stagnation，heat grows and obstructs the kidney meridians，and the treatment is to remove blood stasis，eliminate signs，clear heat，and unblock collaterals. Professor ZHANG emphasizes that in the late stage of the disease or after treatment of hormones，immunosuppressive agents，etc.，patients are often in a combined situation of deficiency，dampness，and heat，and the modified medication based on self-made Xiaodanban Prescription is necessary. In clinical practices，Professor ZHANG often uses a large amount of Astragali Radix，Atractylodis Macrocephalae Rhizoma，and other qi- replenishing medicinals to supplement the kidney and fortify the spleen； he also skillfully uses Notoginseng Radix et Rhizoma， Houttuyniae Herba， Pheretima， and other insect medicinals to promoting blood circulation and removing stasis，and attaches great importance to dispelling wind and dampness，promoting blood circulation，and unblocking meridians， making treatment more efficient， shortening the course of the disease， reaching the root of disease directly，and alleviating the pain of patients.