Abstract： Objective： To investigate the action mechanism of Jiujian Gualou Xiebai Banxia Decoction for coronary heart disease (CHD) by mass spectrographic analysis， network pharmacology and molecular docking techniques. Methods： Ultra-performance liquid chromatography-quadrupole time-of-flight dem mass spectrometry (UPLC-Q-TOF / MS) was used to identify the components of Jiujian Gualou Xiebai Banxia Decoction；the targets of CHD disease were found according to Gene Cards database and DisGeNET database； Metascape online analysis website was used to cluster analyze gene targets and pathways； a network diagram of Chinese medicine-active ingredient-target interaction mechanism was constructed； AutoDockTools software was used to complete the molecular docking of target genes and key active ingredients. Results： A total of 76 chemical components of Jiujian Gualou Xiebai Banxia Decoction were identified by spectrographic analysis，751 medicine-related targets and 1 249 disease-related targets were obtained by database screening，and 190 potential targets were obtained by intersection of the two. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis results were mainly related to lipid and atherosclerosis，fluid shear stress and atherosclerosis，cGMP-PKG pathway，calcium signaling pathway， and PPAR signaling pathway. Molecular docking results showed that the protein represented by Peroxisome proliferator-activated receptor δ (PPARD) ， peroxisome proliferator-activated receptor γ (PPARG)， platelet activating factor receptor (PTAFR)， estrogen receptor 2 (ESR2)， androgen receptor (AR)， and retinoic acid X-receptor α (RXRA) showed a good binding ability with three active ingredients， namely demethylhomopterocarpin，Garmin and Cyclo (leucine-tyrosine). Conclusion：Jiujian Gualou Xiebai Banxia Decoction can achieve therapeutic effects on CHD by activating targets of PPARA， PPARG， PPARD，ESR2，AR and RXRA，lipid and atherosclerosis， fluid shear stress and atherosclerosis，cGMP-PKG pathway，calcium signaling pathway，and PPAR signaling pathway.