Abstract： Objective： To explore the traditional Chinese medicine (TCM) syndromes and medication characteristics of prescriptions for lung nodules，and to provide diagnosis and treatment ideas for Chinese medicine to treat lung nodules. Methods： The TCM syndromes and prescriptions related to lung nodules recorded from the day of database establishment to December 2022 were collected from China National Knowledge Infrastructure (CNKI)，Wanfang，VIP，SinoMed and PubMed databases. Excel and Traditional Chinese Medicine Inheritance Assistant Platform (V2.5) were used to establish the syndrome and prescription database for statistical analysis，and the rules of TCM syndrome types and medicinal frequency were excavated， and then the core combinations and new prescription combinations were extracted. Results：A total of 145 literature were included；after selection，there were 93 kinds of TCM syndrome types，211 effective prescriptions and 268 Chinese medicinals were selected. Among them，14 syndrome types were with frequency of and over 80. The syndromes of lung nodules were mainly hlegm blended with stasis，and the syndrome elements of disease nature were mainly qi deficiency，phlegm，qi stagnation， blood stasis and yin deficiency；the syndrome elements of disease location were the lung，spleen and liver. The Chinese medicinals used were those for supplementing deficiency， clearing heat， dissolving phlegm and relieving cough and panting， promoting urination and percolating dampness， and invigorating blood and dissolving stasis. There were 16 kinds of commonly used high-frequency Chinese medicinals，and the top 3 were Glycyrrhizae Radix et Rhizoma，Poria and Fritillariae Thunbergii Bulbus. After exploration，there were 16 core combinations， such as Codonopsis Radix-Fagopyri Dibotryis Rhizoma-Scrophulariae Radixand and Asteris Radix et Rhizoma-Farfarae Flos-Ephedrae Herba. There were 8 groups of new prescription combinations， such as Codonopsis Radix-Fagopyri Dibotryis Rhizoma-Scrophulariae Radix- Ostreae Concha-Fritillariae Thunbergii Bulbus and Asteris Radix et Rhizoma-Farfarae Flos-Ephedrae Herba-Eriobotryae Folium-Smilacis Glabrae Rhizoma. Conclusion： For the treatment of lung nodules， zang-fu organs are mainly differentiated. The syndrome types of lung nodules are mostly deficiency-excess complex. In the treatment， mainly-used Chinese medicinals are those for supplementing， boosting and reinforcing healthy qi， dissolving phlegm and dissipating masses， softening hardness and dissipating masses， clearing heat， resolving toxins and dissipating masses， and invigorating blood and dissolving stasis. These have certain reference for diagnosis and treatment of lung nodules， but further clinical and basic researches are still needed to verify the conclusion.