Abstract：Objective：To explore the mechanism of Yigong San Prescription in treating bronchial asthma (BA) by using network pharmacology， molecular docking. Methods： The potential active constituents and corresponding targets of each Chinese medicinal of Yigong Powder were obtained through BATMAN-TCM， ETCM， SymMap， TCM Database@Taiwan and Traditional Chinese Medicine Systems Pharmoncology (TCMSP). DisGeNET， TTD， GeneCards， PharmGkb， Online Mendelian Inheritance in Man (OMIM)， NCBI，Human Phenotypic Ontology (HPO) and Drugbank database were used to collect targets of action of BA. The Bioinformatics & Evolutionary Genomics was used to screen the common targets of medicine and disease. GEO was used to download gene chips， and R language was used to analyze and obtain differentially-expressed genes. Key targets were obtained through cross-validation with common target genes of medicine and disease， and an "active constituents-key targets" network was constructed. R software was used for gene ontology (GO) biological function analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for key targets. The interaction relationship of key target proteins was obtained by using STRING database and Cytoscape software to screen out the core targets. AutoDock software was used to verify the molecular docking between the core targets and the active constituents. Results：A total of 176 active constituents and their corresponding 265 targets of action were screened， and 1 263 differential genes were obtained. A total of 16 key targets including Pim-1 protooncogene (PIM1)， β2 adrenergic receptor (ADRβ2)， Recombinant V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA) ， carbonic anhydrase 2 (CA2) gene and tumor necrosis factor (TNF) were identified by cross-validation. The associated active constituents were quercetin， glycyrrhizin A， glycyrrhizin B，kaempferol，naringin，etc.. The key target enrichment pathways of Yigong San Prescription for BA included NOD-like receptor signaling pathway， C-type lectin receptor signaling pathway， TNF signaling pathway， etc.. Molecular docking results showed that core targets， such as TNF， RELA， Interleukin 1A (IL1A)， catenin β1 (CTNNβ1)， conserved helix-loop-helix ubiquitous kinase (CHUK)， chemokine (C-X-C motif) ligand 2 (CXCL2)， phosphatase and tensin homolog (PTEN)， signal transducer and activator of transcription 1 (STAT1) and so on，had good binding ability with quercetin，glycyrrhizin A， glycyrrhizin B，kaempferol，naringin and other active constituents. Conclusion：Quercetin，glycyrchalcone A，glycyrchalcone B and other constituents in Yigong San Prescription can regulate NOD receptor，C-type lectin receptor signaling pathway， TNF signaling pathway and other signaling pathways through PIM1， ADRβ2 and other targets in the treatment of BA.