Abstract：Objective：To discuss the distribution rules of traditional Chinese medicine (TCM) syndrome types of sepsis and the contributory factors of its prognosis， and to analyze the value of antithrombin Ⅲ (AT-III)， N-terminal pro-brain natriuretic peptide (NT-proBNP) and score of Sequential Organ Failure Assessment (SOFA) in the evaluation of prognosis of sepsis. Methods：A total of 148 patients with sepsis were selected as the study subjects and the distribution rules of TCM syndrome types were summarized. They were divided into the survival group and the death group according to the prognosis profile ， with 115 and 33 cases in each group. The related contributory factors of prognosis of patients with sepsis were analyzed by univariate and multivariate logistic regression. The value of AT- Ⅲ ， NT-proBNP and SOFA score in the evaluation of the prognosis were evaluated by drawing the receiver operating characteristic curve (ROC). Results：The distribution of TCM syndrome types in 148 patients with sepsis was ranked from high to low in order of frequency was respectively 64 cases (43.24%) with acute deficiency syndrome ， 35 (23.65%) with toxin-heat syndrome，31 (20.95%) with blood stasis syndrome，and 18 (12.16%) with bowel qi obstruction syndrome. The proportion of acute deficiency syndrome in the death group was higher than that in the survival group (P＜0.05). The acute deficiency syndrome，decreased AT-III，increased NTproBNP， SOFA score and being male were the risky factors of death of patients with sepsis (P＜0.05). The areas under the ROC of AT- Ⅲ ， NT-proBNP and SOFA score in predicting the death of sepsis patients were respectively 0.676，0.715 and 0.724. When the three indexes were combined for diagnosis，the area under the ROC was increased to 0.8， and the sensitivity was as high as 90.9%. Conclusion： The distribution of TCM syndrome types of sepsis in sequence is acute deficiency syndrome， toxin-heat syndrome， blood stasis syndrome， and bowel qi obstruction syndrome. The acute deficiency syndrome， decreased AT- Ⅲ ， increased NT-proBNP， SOFA score and being male are the risky factors of death of patients with sepsis. The therapy of AT- Ⅲ combined with NT-proBNP and SOFA score can effectively enhance the accuracy in early prediction of death of patients with sepsis.