Abstract：Objective：To observe the clinical effect of the therapy of Xingqi Huayu Xiaozheng Decoction combined with western medicine on chronic pelvic inflammatory disease (CPID) with syndrome of qi stagnation and blood stasis. Methods：A total of 106 cases of CPID patients with syndrome of qi stagnation and blood stasis were selected and divided into the control group and the study group according to the random number table method， with 53 cases in each group. The control group was treated with Levofloxacin Hydrochloride Tablets and Metroidazole Tablets，and the study group was additionally treated with Xingqi Huayu Xiaozheng Decoction based on the treatment of the control group. The two groups were treated for 4 weeks and followed up for 6 months. The clinical effects，traditional Chinese medicine (TCM) syndrome scores， levels of inflammation indexes [interleukin-6 (IL-6)， interleukin-10 (IL-10)， tumor necrosis factor- α (TNF- α) and hypersensitive C-reactive protein (hs-CRP)]， levels of hemodynamics indexes [pulsitility index (PI)，resistance index (RI) and maximum blood flow velocity (Vmax) of pelvic cavity] and recurrence rates were compared between the two groups. Results： After treatment， the total effective rate was 94.34% in the study group， higher than that of 81.13% in the control group (P＜0.05). After treatment， the scores of distending pain in lumbosacral spine， sharp or distending pain in lower abdomen，large leukorrhea amount，emotional depression，distending pain in breasts，increased ovarian volume and dark red menses or with clotted blood in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above seven TCM syndrome scores in the study group were lower than those in the control group (P＜0.05). After treatment，the levels of serum IL-6，TNF-α and hs- CRP in the two groups were decreased when compared with those before treatment (P＜0.05)， and the serum IL-10 levels were increased when compared with those before treatment (P＜0.05)； the levels of serum IL-6，TNF-α and hs-CRP in the study group were lower than those in the control group (P＜0.05)， and the serum IL-10 level was higher than that in the control group (P＜0.05). After treatment，the PI and RI in the two groups were decreased when compared with those before treatment (P＜0.05)，and the Vmax was increased when compared with that before treatment (P＜0.05)；the PI and RI in the study group were lower than those in the control group (P＜0.05)，and the Vmax was higher than that in the control group (P＜ 0.05). After follow-up of 6 months，the recurrence rate was 4.00% in the study group，lower than that of 16.28% in the control group (P＜0.05). Conclusion： The therapy of Xingqi Huayu Xiaozheng Decoction combined with western medicine can enhance the curative effect on CPID with syndrome of qi stagnation and blood stasis，mitigate the clinical symptoms，control the inflammatory responses，improve the blood flow of pelvic cavity and decrease the recurrence rate.