Abstract：Objective：To observe the clinical effect of modified Chaihu Plus Longgu Muli Decoction in adjuvant treatment of gastroesophageal reflux disease of liver-stomach heat constraint type. Methods： A total of 96 cases of patients with gastroesophageal reflux disease of liver-stomach heat constraint type were divided into the treatment group and the control group according to the random number table method， with 48 cases in each group. The control group was treated with Esomeprazole and Mosapride， and the treatment group was additionally treated with modified Chaihu Plus Longgu Muli Decoction based on the treatment of the control group. Both groups were continuously treated for 8 weeks. The scores of the Reflux Disease Questionnaire (RDQ)， grading of esophageal mucosa， traditional Chinese medicine (TCM) syndromes，Pittsburgh Sleep Quality Index (PSQI) Scale and the 36-Item Short Form Health Survey (SF-36)， and esophageal dynamic indicators before and after treatment， as well as clinical effects were compared between the two groups. Results： After treatment， the total effective rate was 89.58% in the treatment group，higher than that of 75.00% in the control group (P＜0.05). After treatment，TCM syndrome scores， RDQ scores，grading scores of esophageal mucosa，and PSQI scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the treatment group were lower than those in the control group (P＜0.05). Resting pressure in the lower esophageal sphincter，distal contractile integral，and SF-36 scores in the two groups were increased when compared with those before treatment (P＜0.05)， and the above esophageal dynamic indicators and SF-36 scores in the treatment group were higher than those in the control group (P＜0.05). Conclusion：Modified Chaihu Plus Longgu Muli Decoction has a definite curative effect in the adjuvant treatment of gastroesophageal reflux disease of liverstomach heat constraint type， which can alleviate gastrointestinal symptoms in patients， improve esophageal dynamics，and enhance sleep and quality of life.