Abstract：Objective：To observe the clinical effect of Fangji Huangqi Decoction and Sijunzi Decoction assisted with conventional western medicine on the treatment of cirrhosis and ascites. Methods：A total of 104 patients with cirrhosis and ascites were divided into the study group and the control group by random number table method，with 52 cases in each group. Both groups were treated with conventional western medicine， and the study group was additionally given Fangji Huangqi Decoction and Sijunzi Decoction on this basis. The clinical effects， clinical indicators， liver function and liver fibrosis indicators in the two groups were compared. Results：After treatment，the total effective rate was 92.31% in the study group， higher than that of 76.92% in the control group (P＜0.05). After treatment，the 24-hour urine volume in the two groups was increased (P＜0.05)，and the 24-hour urine volume in the study group was more than that in the control group (P＜0.05)； the abdominal circumference， body mass and ascites depth in the two groups were decreased (P＜0.05)，and the above three indexes in the study group were less than those in the control group (P＜0.05). After treatment， the levels of aspartate aminotransferase (AST)， alanine aminotransferase (ALT) and total bilirubin (TBil) in the two groups were decreased (P＜0.05)，and the above levels in the study group were lower than those in the control group (P＜0.05). After treatment，the levels of hyaluronic acid (HA)， laminin (LN)， type Ⅳcollagen ( Ⅳ-C) and type Ⅲprocollagen (PC Ⅲ) in the two groups were decreased (P＜0.05)， and the above levels in the study group were lower than those in the control group (P＜0.05). Conclusion： The therapy of Fangji Huangqi Decoction and Sijunzi Decoction assisted with conventional western medicine has a significant clinical effect on the treatment of cirrhosis and ascites，which can increase 24-hour urine volume，reduce abdominal circumference，body mass and ascites depth，improve liver function and liver fibrosis degree.