Abstract： Objective： To observe the effects of the therapy of Shenling Baizhu San combined with resistance training on the nutritional status and muscle strength of patients with atrophy of spleen-stomach weakness type. Methods： A total of 80 patients with atrophy of spleen-stomach weakness type were selected and divided into the control group and the treatment group according to the random number table method，with 40 cases in each group. The control group was given resistance training for treatment，and the treatment group was treated with Shenling Baizhu San combined with resistance training. The clinical effects and the changes in nutritional status [serum total protein (TP)，prealbumin (PA) and serum albumin (Alb)] and muscle strength [Manual Muscle Testing (MMT)，Short Physical Performance Battery (SPPB) and Osserman grade] were compared before and after treatment between the two groups. Results：The total clinical effective rate was 95.00% in the treatment group，and 77.50% in the control group，the difference being significant (P＜0.05). After treatment， the levels of serum TP， Alb and PA in the two groups were increased when compared with those before treatment (P＜0.05)， and the above three levels in the treatment group were higher than those in the control group (P＜0.05). After treatment，the MMT scores in the two groups were increased when compared with those before treatment (P＜0.05)， and the MMT score in the treatment group was higher than that in the control group (P＜0.05). After treatment， the Osserman grade in the two groups was decreased when compared with that before treatment (P＜0.05)， and the SPPB scores were increased when compared with those before treatment (P＜0.05)； the Osserman grade in the treatment group was lower than that in the control group (P＜0.05)，and the SPPB score was higher than that in the control group (P＜0.05). Conclusion：The therapy of Shenling Baizhu San combined with resistance training has a great curative effect on patients with atrophy disease of spleenstomach weakness type，which can improve the nutritional status and enhance the musculation ability and the muscle function.