Abstract： Objective： To observe the curative effect of the therapy of Qingre Tiaoxue Decoction combined with gonadotropin-releasing hormone agonist (GnRh-a) on endometriosis (EMs) of damp-heat stasis obstruction type. Methods：A total of 70 EMs patients were selected and divided into the observation group and the control group according to random number table method，with 35 patients in each group. The control group was treated with Leuprelin Acetate Microspheres，and the observation group was additionally given Qingre Tiaoxue Decoction based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effects in the two groups were evaluated，and the scores of Visual Analogue Scale of pain (VAS)， levels of serum carbohydrate antigen 125 (CA125)， sex hormone levels， serum matrix metalloproteinase (MMP) -9， vascular endothelial growth factor (VEGF)， tumor necrosis factor (TNF) - α levels were compared between the two groups. Results： The total effective rate was 94.29% in the observation group，higher than that of 71.43% in the control group (P＜0.05). After 6 weeks and 12 weeks of treatment，the VAS scores in the two groups were gradually decreased (P＜0.05)，and the VAS scores in the observation group were lower than those in the control group at the same time point (P＜0.05). After 6 and 12 weeks of treatment，the serum CA125 levels in both groups were gradually decreased (P＜0.05)， and the serum CA125 level in the observation group was lower than that in the control group at the same time point (P＜0.05). After treatment，the levels of serum E2，FSH，LH，MMP-9，VEGF and TNF- α in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of serum E2，FSH，LH，MMP-9，VEGF and TNF- α in the observation group were lower than those in the control group (P＜0.05). Conclusion：The therapy of Qingre Tiaoxue Decoction combined with GnRH-a can improve the therapeutic effect on EMs of damp-heat stasis obstruction type，relieve pain，improve CA125 and sex hormone levels，and inhibit inflammatory injury and vascular formation.