Abstract： Objective： To observe the clinical effect of Yishen Huayu Cuyun Decoction for infertility caused by polycystic ovary syndrome (PCOS). Methods： A total of 132 cases of patients with infertility caused by PCOS were selected and divided into the control group and the observation group according to random number table method， with 66 cases in each group. The control group was treated with routine treatment of western medicine， and the observation group was additionally given Yishen Huayu Cuyun Decoction based on the treatment of the control group. Both groups were treated for 3 menstrual cycles. The ovulation rate and pregnancy rates after treatment were counted in two groups. The levels of inflammatory factors， sex hormones， and endometrial receptivity were compared before and after treatment between the two groups. Results： The ovulation rate was 94.94% in the observation group， higher than that of 74.24% in the control group (P＜0.05)； the pregnancy rate was 84.85% in the observation group，higher than that of 66.67% in the control group (P＜0.05). After treatment，the levels of serum transforming growth factor-β1 (TGF-β1) and interleukin-6 (IL-6) in the two groups were decreased when compared with those before treatment，and the levels of sex hormone binding globulin (SHBG) were increased when compared with those before treatment (P＜0.05)；the levels of TGF-β1 and IL-6 in serum in the observation group were lower than those in the control group， and SHBG level in the observation group was higher than that in the control group (P＜0.05). After treatment， the serum estradiol (E2)， luteinizing hormone (LH)， and LH/follicle stimulating hormone (FSH) in the two groups were decreased when compared with those before treatment (P＜0.05)；the levels of E2，LH and LH/FSH in serum in the observation group were lower than those in the control group (P＜0.05). After treatment，the resistance to blood flow in endometrial spiral artery in the two groups was decreased when compared with that before treatment，and the thickness of endometrium on ovulation day was increased (P＜0.05)；the resistance to blood flow in endometrial spiral artery in the observation group was lower than that in the control group， and the thickness of endometrium on ovulation day in the observation group was larger than that in the control group (P＜0.05). After treatment， the proportion of type A endometrium in the two groups was increased when compared with that before treatment (P＜0.05)； the proportion in the observation group was higher than that in the control group (P＜0.05). Conclusion： Yishen Huayu Cuyun Decoction for infertility caused by PCOS can relieve inflammatory responses，regulate sex hormones，prevent fibrosis， improve endometrial receptivity，and enhance clinical effects.