Abstract： Objective： To observe the curative effect of the therapy of acupuncture combined with routine therapy on spinal cord injuries. Methods： A total of 94 patients with spinal cord injuries were selected and divided into the routine group and the acupuncture group according to the random number table method， with 47 cases in each group. The routine group was given routine therapy， and the acupuncture group was additionally treated with acupuncture based on the treatment of the routine group. The clinical effects， and the changes in 24-hour leakage of urine frequency， voided volume each time， 24-hour urination frequency， residual urine volume， the scores of Incontinence Questionnaire-Urinary Incontinence Short Form (ICI-Q-SF)， Visual Analogue Scale (VAS) and Incontinence Quality of Life Scale (I-QOL)， bladder compliance， maximum urethral closure pressure， abdominal leak point pressure， maximum cystometric capacity，motor evoked potentials (MEP) of tibialis anterior，resting motor threshold (RMT)， monocyte chemotactic protein-1 (MCP-1)， nuclear factor- κB (NF- κB)， and heat shock protein 70 (HSP70) were compared before and after treatment between the two groups. Results： The total effective rate was 97.87% in the acupuncture group， and 82.98% in the routine group， the difference being significant (P＜0.05). After treatment，the voided volume each time in the two groups was increased when compared with that before treatment (P＜0.05)， the 24-hour leakage of urine frequency， residual urine volume and 24-hour urination frequency were decreased when compared with those before treatment (P＜0.05)； the voided volume each time in the acupuncture group was higher than that in the routine group (P＜0.05)，and the 24-hour leakage of urine frequency，residual urine volume and 24-hour urination frequency were less than those in the routine group (P＜0.05). After treatment，the scores of ICIQ- SF and VAS in the two groups were decreased when compared with those before treatment (P＜0.05)， and the I-QOL scores were increased when compared with those before treatment (P＜0.05)；the scores of ICI-Q-SF and VAS in the acupuncture group were lower than those in the routine group (P＜0.05)，and the I-QOL score was higher than that in the routine group (P＜0.05). After treatment， the bladder compliance， maximum urethral closure pressure， abdominal leak point pressure and maximum cystometric capacity in the two groups were increased when compared with those before treatment (P＜ 0.05)，and the above four indexes in the acupuncture group were higher than those in the routine group (P＜ 0.05). After treatment， the MEP amplitude in the two groups was increased when compared with that before treatment (P＜0.05)，and the RMT was decreased when compared with that before treatment (P＜ 0.05)； the MEP amplitude in the acupuncture group was higher than that in the routine group (P＜0.05)， and the RMT was lower than that in the routine group (P＜0.05). After treatment，the levels of MCP-1 and NF-κB in the two groups were decreased when compared with those before treatment (P＜0.05)，and the HSP70 levels were increased when compared with those before treatment (P＜0.05)；the levels of MCP-1 and NF-κB in the acupuncture group were lower than those in the routine group (P＜0.05)，and the HSP70 level was higher than that in the routine group (P＜0.05). Conclusion：The therapy of acupuncture combined with routine therapy has a great curative effect on spinal cord injuries， which can regulate the indexes of urodynamics and neuroelectrophysiology，improve the urge incontinence and neuropathic pain of patients， and inhibit the microenvironment inflammatory responses of the body.